Association between the perturbation of bile acid homeostasis and valproic acid-induced hepatotoxicity.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.113669
Abstract: Valproic acid (VPA), a widely prescribed antiepileptic drug, is known to induce hepatotoxicity. However, the mechanisms underlying this toxicity are not well understood. In this study, we performed a nontargeted metabolomic analysis of children with… read more here.
Keywords: vpa; acid homeostasis; hepatotoxicity; bile acid ... See more keywords
Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.103089
Abstract: Summary Cellular cholesterol is regulated by at least two transcriptional mechanisms involving sterol-regulatory-element-binding proteins (SREBPs) and liver X receptors (LXRs). Although SREBP and LXR pathways are the predominant mechanisms that sense cholesterol in the endoplasmic… read more here.
Keywords: homeostasis; acid homeostasis; cholesterol; mice ... See more keywords
Estimating the number of protein molecules in a plant cell: protein and amino acid homeostasis during drought.
Sign Up to like & getrecommendations! Published in 2021 at "Plant physiology"
DOI: 10.1093/plphys/kiaa050
Abstract: During drought stress, cellular proteostasis on the one hand and amino acid homeostasis on the other hand are severely challenged, because the decrease in photosynthesis induces massive proteolysis, leading to drastic changes in both the… read more here.
Keywords: amino; amino acid; acid homeostasis; protein molecules ... See more keywords
Paeoniflorin alleviates 17α-ethinylestradiol-induced cholestasis via the farnesoid X receptor-mediated bile acid homeostasis signaling pathway in rats
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1064653
Abstract: Cholestasis, characterized by disturbance of bile formation, is a common pathological condition that can induce several serious liver diseases. As a kind of trigger, estrogen-induced cholestasis belongs to drug-induced cholestasis. Paeoniflorin is the most abundant… read more here.
Keywords: cholestasis; medicine; paeoniflorin; acid homeostasis ... See more keywords
Pyrrolizidine Alkaloids Disturb Bile Acid Homeostasis in the Human Hepatoma Cell Line HepaRG
Sign Up to like & getrecommendations! Published in 2021 at "Foods"
DOI: 10.3390/foods10010161
Abstract: 1,2-unsaturated pyrrolizidine alkaloids (PAs) belong to a group of secondary plant metabolites. Exposure to PA-contaminated feed and food may cause severe hepatotoxicity. A pathway possibly involved in PA toxicity is the disturbance of bile acid… read more here.
Keywords: acid homeostasis; human hepatoma; bile acid; pyrrolizidine alkaloids ... See more keywords
GPRC6A Mediates Glucose and Amino Acid Homeostasis in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12080740
Abstract: GPRC6A, an important member of the G-protein-coupled receptor superfamily, has been widely studied in body health maintenance and related diseases. However, it is still controversial whether GPRC6A plays a vital role in glucose homeostasis, and… read more here.
Keywords: gprc6a; role; acid homeostasis; amino acid ... See more keywords
Pre-cold stress increases acid stress resistance and induces amino acid homeostasis in Lactococcus lactis NZ9000
Sign Up to like & getrecommendations! Published in 2017 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v16i6.20
Abstract: Purpose: To investigate the effects of pre-cold stress treatments on subsequent acid stress resistance and the viability of Lactococcus lactis during acid fermentation. Methods: Bacterial strains were grown at 4 °C for 2 h pre-adaptation,… read more here.
Keywords: amino acid; acid homeostasis; stress resistance; stress ... See more keywords