Age-Dependent Increase in Schmidt-Lanterman Incisures and a Cadm4-Associated Membrane Skeletal Complex in Fatty Acid 2-hydroxylase Deficient Mice: a Mouse Model of Spastic Paraplegia SPG35.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular neurobiology"
DOI: 10.1007/s12035-022-02832-4
Abstract: PNS and CNS myelin contain large amounts of galactocerebroside and sulfatide with 2-hydroxylated fatty acids. The underlying hydroxylation reaction is catalyzed by fatty acid 2-hydroxylase (FA2H). Deficiency in this enzyme causes a complicated hereditary spastic… read more here.
Keywords: spastic paraplegia; mice; acid hydroxylase; fatty acid ... See more keywords
Expression and characterization of the benzoic acid hydroxylase CYP199A25 from Arthrobacter sp.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Catalysis"
DOI: 10.1016/j.mcat.2019.110739
Abstract: Abstract Metabolically diverse organisms can serve as valuable source for Cytochrome P450 monooxygenases (CYPs), extending the repertoire of biocatalysts for C–H bond oxyfunctionalization. Here, we report on the cloning, expression and characterization of two new P450 s… read more here.
Keywords: acid hydroxylase; expression characterization; cyp199a25; benzoic acid ... See more keywords
S5H/DMR6 Encodes a Salicylic Acid 5-Hydroxylase That Fine-Tunes Salicylic Acid Homeostasis1[OPEN]
Sign Up to like & getrecommendations! Published in 2017 at "Plant Physiology"
DOI: 10.1104/pp.17.00695
Abstract: SALICYLIC ACID 5-HYDROXYLASE catalyzes the formation of 2,5-DHBA both in vitro and in vivo and fine-tunes SA homeostasis in Arabidopsis. The phytohormone salicylic acid (SA) plays essential roles in biotic and abiotic responses, plant development,… read more here.
Keywords: acid hydroxylase; salicylic acid; s5h dmr6;
A new model for fatty acid hydroxylase-associated neurodegeneration reveals mitochondrial and autophagy abnormalities
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1000553
Abstract: Fatty acid hydroxylase-associated neurodegeneration (FAHN) is a rare disease that exhibits brain modifications and motor dysfunctions in early childhood. The condition is caused by a homozygous or compound heterozygous mutation in fatty acid 2 hydroxylase… read more here.
Keywords: hydroxylase associated; acid hydroxylase; model; fahn ... See more keywords
Nimodipine but Not Nifedipine Promotes Expression of Fatty Acid 2-Hydroxylase in a Surgical Stress Model Based on Neuro2a Cells
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18050964
Abstract: Nimodipine is well characterized for the management of aneurysmal subarachnoid hemorrhage and has been shown to promote a better outcome and less delayed ischemic neurological deficits. Animal and clinical trials show neuroprotective efficacy following nerve… read more here.
Keywords: acid hydroxylase; fatty acid; stress; nimodipine nifedipine ... See more keywords
4-Arylthiosemicarbazide Derivatives as Toxoplasmic Aromatic Amino Acid Hydroxylase Inhibitors and Anti-inflammatory Agents
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DOI: 10.3390/ijms23063213
Abstract: Approximately one-third of the human population is infected with the intracellular cosmopolitan protozoan Toxoplasma gondii (Tg), and a specific treatment for this parasite is still needed. Additionally, the increasing resistance of Tg to drugs has… read more here.
Keywords: acid hydroxylase; anti inflammatory; arylthiosemicarbazide derivatives; amino acid ... See more keywords
Fatty Acid 2-Hydroxylase and 2-Hydroxylated Sphingolipids: Metabolism and Function in Health and Diseases
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054908
Abstract: Sphingolipids containing acyl residues that are hydroxylated at C-2 are found in most, if not all, eukaryotes and certain bacteria. 2-hydroxylated sphingolipids are present in many organs and cell types, though they are especially abundant… read more here.
Keywords: acid hydroxylase; fatty acid; hydroxylated sphingolipids; metabolism function ... See more keywords