Deep indel mutagenesis reveals the impact of amino acid insertions and deletions on protein stability and function
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DOI: 10.1038/s41467-025-57510-5
Abstract: Amino acid insertions and deletions (indels) are an abundant class of genetic variants. However, compared to substitutions, the effects of indels on protein stability are not well understood and are poorly predicted. To better understand… read more here.
Keywords: acid insertions; stability; insertions deletions; protein stability ... See more keywords
Epistatic Effects Between Amino Acid Insertions and Substitutions Mediate Toxin resistance of Vertebrate Na+,K+-ATPases
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msac258
Abstract: The recurrent evolution of resistance to cardiotonic steroids (CTS) across diverse animals most frequently involves convergent amino-acid substitutions to the H1-H2 extracellular loop of Na+,K+-ATPase (NKA). Previous work established that hystricognath rodents (e.g. chinchilla) and… read more here.
Keywords: effects amino; acid insertions; resistance; amino acid ... See more keywords