Tetrazole as a Carboxylic Acid Isostere and the Synthesis of All Amine-Based Polyampholytes.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202200096
Abstract: A new family of polyampholytes (PAMs) is described in which both the basic and acidic groups are based on nitrogen functional groups. RAFT-prepared poly(pentafluorophenyl acrylate) was quantitatively modified sequentially with 3-picolylamine and 5-aminotetrazole, yielding the… read more here.
Keywords: carboxylic acid; isostere synthesis; tetrazole carboxylic; amine based ... See more keywords
Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.2c00434
Abstract: Among the most important influenza virus targets is the RNA-dependent RNA polymerase acidic N-terminal (PAN) endonuclease, which is a critical component of the viral replication machinery. To inhibit the activity of this metalloenzyme, small-molecule inhibitors… read more here.
Keywords: carboxylic acid; derivatives hydroxypyridinones; core scaffolds; hydroxypyridinones core ... See more keywords