LC-MS/MS assay coupled with carboxylic acid magnetic bead affinity capture to quantitatively measure cationic host defense peptides (HDPs) in complex matrices with application to preclinical pharmacokinetic studies.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113093
Abstract: Synthetic host defense peptides (HDP) are a new class of promising therapeutic agents with potential application in a variety of diseases. RP-182 is a 10mer synthetic HDP design, which selectively reduces M2-like tumor associated macrophages… read more here.
Keywords: acid magnetic; defense; defense peptides; carboxylic acid ... See more keywords
Aminated β-cyclodextrin-grafted Fe3O4-loaded gambogic acid magnetic nanoparticles: preparation, characterization, and biological evaluation
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c9ra04955j
Abstract: Based on aminated β-cyclodextrin (6-NH2-β-CD)-grafted Fe3O4 and gambogic acid clathrate complexes, a nanoparticle delivery system was developed with the aim of achieving low irritation, strong targeting and high bioavailability of a gambogic acid magnetic nanopreparation. read more here.
Keywords: acid magnetic; cyclodextrin grafted; aminated cyclodextrin; gambogic acid ... See more keywords