Fatty acid metabolism and prospects for targeted therapy of cancer
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Lipid Science and Technology"
DOI: 10.1002/ejlt.201600366
Abstract: Fatty acids are fundamental substrates required for energy storage, synthesis of membranes, generation of signaling molecules and lipid droplet formation in cancer cells. High levels of fatty acid metabolic activity are one of the most… read more here.
Keywords: acid metabolism; fatty acid; cancer cells; cancer ... See more keywords
Transpulmonary amino acid metabolism in the sugen hypoxia model of pulmonary hypertension
Sign Up to like & getrecommendations! Published in 2023 at "Pulmonary Circulation"
DOI: 10.1002/pul2.12205
Abstract: Abstract In pulmonary artery hypertension (PAH), emerging evidence suggests that metabolic abnormalities may be contributing to cellular dysfunction in PAH. Metabolic abnormalities such as glycolytic shift have been observed intracellularly in several cell types in… read more here.
Keywords: sugen hypoxia; acid metabolism; metabolic abnormalities; amino acid ... See more keywords
Fatty acid metabolism in the progression and resolution of CNS disorders.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2020.01.004
Abstract: Recent advances in lipidomics and metabolomics have unveiled the complexity of fatty acid metabolism and the fatty acid lipidome in health and disease. A growing body of evidence indicates that imbalances in the metabolism and… read more here.
Keywords: acid metabolism; metabolism; fatty acid; cns disorders ... See more keywords
Dietary zinc levels affects lipid and fatty acid metabolism in hepatopancreas of mud crab (Scylla paramamosain)
Sign Up to like & getrecommendations! Published in 2021 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2021.737274
Abstract: Abstract This study investigated the influences of dietary zinc (Zn) on lipid and fatty acid metabolism of Scylla paramamosain. Three diets containing analyzed Zn levels including 44.5 (low Zn), 68.5 (medium Zn) and 254.7 (high… read more here.
Keywords: mud crab; acid metabolism; fatty acid; lipid fatty ... See more keywords
Amino acid metabolism as drug target in autoimmune diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2019.02.004
Abstract: In mammals, amino acid metabolism has evolved to control immune responses. Autoimmune diseases are heterogeneous conditions that involve the breakdown of tolerogenic circuitries and consequent activation of autoreactive immune cells. Therefore, critical enzymes along amino… read more here.
Keywords: metabolism drug; autoimmune diseases; amino acid; acid metabolism ... See more keywords
Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer cell"
DOI: 10.1016/j.ccell.2019.12.011
Abstract: Metabolic pathways must be adapted to support cell processes required for transformation and cancer progression. Amino acid metabolism is deregulated in many cancers, with changes in branched-chain amino acid metabolism specifically affecting cancer cell state… read more here.
Keywords: amino acid; acid metabolism; metabolism; branched chain ... See more keywords
Exposure to GenX and its novel analogs disrupts fatty acid metabolism in male mice.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental pollution"
DOI: 10.1016/j.envpol.2021.118202
Abstract: Perfluoroalkyl ether carboxylic acids (PFECAs), including hexafluoropropylene oxide dimer acid (HFPO-DA, GenX), have been widely used as alternatives to perfluorooctanoic acid (PFOA) and subsequently detected in various environmental matrices. Despite this, public information regarding their… read more here.
Keywords: male mice; fatty acid; genx; acid metabolism ... See more keywords
Disrupted metabolic pathways and potential human diseases induced by bisphenol S.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2021.103751
Abstract: Although the toxicity of bisphenol S has been studied in some species, the global metabolic network disrupted by bisphenol S remains unclear. To this end, published datasets related to the genes, proteins, and metabolites disturbed… read more here.
Keywords: pathways potential; bisphenol; acid metabolism; metabolism ... See more keywords
Lipoic acid metabolism in Trypanosoma cruzi as putative target for chemotherapy.
Sign Up to like & getrecommendations! Published in 2018 at "Experimental parasitology"
DOI: 10.1016/j.exppara.2018.01.017
Abstract: Lipoic acid (LA) is a cofactor of relevant enzymatic complexes including the glycine cleave system and 2-ketoacid dehydrogenases. Intervention on LA de novo synthesis or salvage could have pleiotropic deleterious effect in cells, making both… read more here.
Keywords: chemotherapy; acid metabolism; acid; trypanosoma cruzi ... See more keywords
Low-temperature stress-induced aroma loss by regulating fatty acid metabolism pathway in 'Nanguo' pear.
Sign Up to like & getrecommendations! Published in 2019 at "Food chemistry"
DOI: 10.1016/j.foodchem.2019.05.201
Abstract: Low temperatures retard postharvest ripening and prolong the supply period of 'Nanguo' pears. However, quality deterioration, or more specifically, a faded aroma occurs in long-term cold-stored fruits. To understand the implicit mechanism, we analyzed the… read more here.
Keywords: metabolism pathway; cold stored; fruit; fatty acid ... See more keywords
Microbiome-encoded bile acid metabolism modulates colonic transit times
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102508
Abstract: Summary Gut motility is regulated by the microbiome via mechanisms that include bile acid metabolism. To localize the effects of microbiome-generated bile acids, we colonized gnotobiotic mice with different synthetic gut bacterial communities that were… read more here.
Keywords: microbiome encoded; acid metabolism; transit; colonic transit ... See more keywords