Detection and confirmation of the ring-opened carboxylic acid metabolite of a new synthetic opioid furanylfentanyl
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DOI: 10.1007/s11419-020-00546-7
Abstract: Purpose Recently, the opioid epidemic has become a serious problem, particularly in North America and Europe. The aim of this study was to clarifyQuery the metabolic fate of a new synthetic opioid furanylfentanyl. Methods The… read more here.
Keywords: opened carboxylic; carboxylic acid; ring opened; acid metabolite ... See more keywords
Effects of CYP2C9 genetic polymorphisms on the pharmacokinetics of celecoxib and its carboxylic acid metabolite
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DOI: 10.1007/s12272-016-0861-2
Abstract: Celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, is used for the treatment of rheumatoid arthritis and osteoarthritis. The predominant hepatic metabolism of celecoxib to celecoxib carboxylic acid (CCA) is mediated mainly by CYP2C9. We investigated the… read more here.
Keywords: pharmacokinetics celecoxib; celecoxib; cyp2c9 genetic; carboxylic acid ... See more keywords
Tricarboxylic Acid Metabolite Imbalance in Rats with Acute Thioacetamide-Induced Hepatic Encephalopathy Indicates Incomplete Recovery
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DOI: 10.3390/ijms24021384
Abstract: Exposure to the toxin thioacetamide (TAA) causes acute hepatic encephalopathy (HE), changes in the functioning of systemic organs, and an imbalance in a number of energy metabolites. The deferred effects after acute HE development are… read more here.
Keywords: hepatic encephalopathy; imbalance; acid metabolite; tricarboxylic acid ... See more keywords
Glyoxylic Acid, an α-Keto Acid Metabolite Derived from Glycine, Promotes Myogenesis in C2C12 Cells
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DOI: 10.3390/nu15071763
Abstract: α-Keto acids may help prevent malnutrition in patients with chronic kidney disease (CKD), who consume protein-restricted diets, because they serve as amino acid sources without producing nitrogenous waste compounds. However, the physiological roles of α-keto… read more here.
Keywords: metabolite derived; glyoxylic acid; acid metabolite; keto acid ... See more keywords