Dexamethasone Conjugation to Biodegradable Avidin-Nucleic-Acid-Nano-Assemblies Promotes Selective Liver Targeting and Improves Therapeutic Efficacy in an Autoimmune Hepatitis Murine Model.
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DOI: 10.1021/acsnano.8b09655
Abstract: Steroids are the standard therapy for autoimmune hepatitis (AIH) but the long-lasting administration is hampered by severe side effects. Methods to improve the tropism of the drug toward the liver are therefore required. Among them,… read more here.
Keywords: acid nano; liver; avidin nucleic; autoimmune hepatitis ... See more keywords
Nano Ellagic Acid Counteracts Cisplatin-Induced Upregulation in OAT1 and OAT3: A Possible Nephroprotection Mechanism
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DOI: 10.3390/molecules25133031
Abstract: Cisplatin is an anticancer drug commonly used for solid tumors. However, it causes nephrotoxicity. OAT1 and OAT3 are organic anion transporters known to contribute to the uptake of cisplatin into renal tubular cells. The present… read more here.
Keywords: oat1 oat3; acid nano; cisplatin; cisplatin induced ... See more keywords