Cellular Uptake Mechanism of Nucleic Acid Nanocapsules and Their DNA-Surfactant Building Blocks.
Sign Up to like & getrecommendations! Published in 2023 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.3c00104
Abstract: Nucleic acid nanocapsules (NANs) are enzyme-responsive DNA-functionalized micelles built for the controlled release of DNA-surfactant conjugates (DSCs) that present sequences with demonstrated therapeutic potential. Here, we investigate the mechanisms by which DSCs gain access to… read more here.
Keywords: nucleic acid; mechanism; cellular uptake; dna surfactant ... See more keywords
Nucleic Acid Nanocapsules for Enzyme-Triggered Drug Release.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.6b13087
Abstract: Herein we describe a nucleic acid functionalized nanocapsule in which nucleic acid ligands are assembled and disassembled in the presence of enzymes. The particles are fully degradable in response to esterases due to an embedded… read more here.
Keywords: nanocapsules enzyme; enzyme triggered; chemistry; acid nanocapsules ... See more keywords