3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O'PROTAC.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06525d
Abstract: In this study, we identified 3-aminophthalic acid as a new ligand of cereblon (CRBN) E3 ubiquitin ligase and developed a phthalic acid-based O'PROTAC for degradation of the ERG transcription factor. This phthalic acid-based O'PROTAC presented… read more here.
Keywords: cereblon; ligand; phthalic acid; degradation ... See more keywords
Spinal tranexamic acid – a new killer in town
Sign Up to like & getrecommendations! Published in 2019 at "Anaesthesia"
DOI: 10.1111/anae.14632
Abstract: 1Assistant Professor, Department of Anesthesiology,WashingtonUniversity School ofMedicine, St. Louis,MO, USA 2Consultant, Department of Anaesthesia, StMichael’s Hospital, Bristol, UK ............................................................................................................................................................................................................................................................................................................ Correspondence to: S.M. Kinsella Email: [email protected] Accepted: 10 February 2019 read more here.
Keywords: acid new; new killer; killer town; tranexamic acid ... See more keywords
Sterile abscess due to hyaluronic acid: A new diagnosis and a proposal for treatment‐A series of eight cases
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cosmetic Dermatology"
DOI: 10.1111/jocd.15135
Abstract: In recent years, fillers procedures with hyaluronic acid (HA) have grown significantly. Despite HA relative safety, the number of cases of complications after injections has grown, and in many of which, we are not aware… read more here.
Keywords: new diagnosis; abscess due; sterile abscess; hyaluronic acid ... See more keywords
Madecassic Acid—A New Scaffold for Highly Cytotoxic Agents
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DOI: 10.3390/ijms23084362
Abstract: Due to their manifold biological activities, natural products such as triterpenoids have advanced to represent excellent leading structures for the development of new drugs. For this reason, we focused on the syntheses and cytotoxic evaluation… read more here.
Keywords: scaffold highly; cytotoxicity; madecassic acid; highly cytotoxic ... See more keywords
Maslinic Acid: A New Compound for the Treatment of Multiple Organ Diseases
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DOI: 10.3390/molecules27248732
Abstract: Maslinic acid (MA) is a pentacyclic triterpene acid, which exists in many plants, including olive, and is highly safe for human beings. In recent years, it has been reported that MA has anti-inflammatory, antioxidant, anti-tumor,… read more here.
Keywords: new compound; multiple organ; maslinic acid; organ diseases ... See more keywords
p-Xylene Oxidation to Terephthalic Acid: New Trends
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DOI: 10.3390/molecules28041922
Abstract: Large-scale terephthalic acid production from the oxidation of p-xylene is an especially important process in the polyester industry, as it is mainly used in polyethylene terephthalate (PET) manufacturing, a polymer that is widely used in… read more here.
Keywords: new trends; terephthalic acid; oxidation terephthalic; xylene oxidation ... See more keywords