Synthetic O-Acetyl-N-glycolylneuraminic Acid Oligosaccharides Reveal Host-Associated Binding Patterns of Coronaviral Glycoproteins.
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DOI: 10.1021/acsinfecdis.2c00046
Abstract: A panel of O-acetylated N-glycolylneuraminic acid oligosaccharides has been prepared by diversification of common synthetic precursors by regioselective de-O-acetylation by coronaviral hemagglutinin-esterase (HE) combined with C7-to-C9 acetyl ester migration. The resulting compound library was printed… read more here.
Keywords: acid oligosaccharides; host; binding patterns; glycolylneuraminic acid ... See more keywords