Expansion of the Substrate Specificity of Porcine Kidney D‐Amino Acid Oxidase for S‐Stereoselective Oxidation of 4‐Cl‐Benzhydrylamine
Sign Up to like & getrecommendations! Published in 2018 at "Chemcatchem"
DOI: 10.1002/cctc.201800614
Abstract: Discovery and development of enzymes for the synthesis of chiral amines have been a hot topic for basic and applied aspects of biocatalysts. Based on our X‐ray crystallographic analyses of porcine kidney D‐amino acid oxidase… read more here.
Keywords: acid oxidase; amino; kidney amino; amino acid ... See more keywords
Insights into the role of d‐amino acid oxidase mutations in amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27529
Abstract: Missense mutations in the coding region of d‐amino acid oxidase (DAO) have been found in patients suffering from amyotrophic lateral sclerosis (ALS). Mutations primarily impair the enzymatic activity of DAO and cause neurodegeneration due to… read more here.
Keywords: acid oxidase; dao mutants; amino acid; amyotrophic lateral ... See more keywords
Solving the H2O2 by-product problem using a catalase-mimicking nanozyme cascade to enhance glycolic acid oxidase
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Engineering Journal"
DOI: 10.1016/j.cej.2020.124249
Abstract: Abstract Self-inactivation of oxidases due to by-product hydrogen peroxide (H2O2) is a main obstacle to applying these enzymes in chemical production. Herein, we report an efficient cascade strategy of co-immobilizing a natural oxidase and catalase-mimicking… read more here.
Keywords: acid oxidase; oxidase; catalase mimicking; product ... See more keywords
Fabrication of enzyme reactor utilizing magnetic porous polymer membrane for screening D-Amino acid oxidase inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "Talanta"
DOI: 10.1016/j.talanta.2016.12.055
Abstract: In this work, a unique D-amino acid oxidase reactor for enhanced enzymolysis efficiency is presented. A kind of magnetic polymer matrices, composed of iron oxide nanoparticles and porous polymer membrane (poly styrene-co-maleic anhydride), was prepared.… read more here.
Keywords: acid oxidase; amino acid; polymer; enzyme reactor ... See more keywords
In vitro cytotoxicity of L‐amino acid oxidase from the venom of Crotalus mitchellii pyrrhus
Sign Up to like & getrecommendations! Published in 2017 at "Toxicon"
DOI: 10.1016/j.toxicon.2017.09.012
Abstract: ABSTRACT L‐amino acid oxidase isolated from Crotalus mitchellii pyrrhus (Cmp‐LAAO) exhibited cytotoxicity against LNCaP prostate adenocarcinoma cells. The viability of LNCaP cells decreased in a concentration‐ and time‐dependent manner upon administration of Cmp‐LAAO. Cmp‐LAAO induced… read more here.
Keywords: acid oxidase; crotalus mitchellii; amino acid; laao ... See more keywords
Direct Fluorescence Evaluation of d-Amino Acid Oxidase Activity Using a Synthetic d-Kynurenine Derivative.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c00775
Abstract: d-Amino acid oxidase (DAO) has been suggested to be associated with the central nervous system diseases, such as schizophrenia. We newly synthesized a nonfluorescent 5-methylthio-d-kynurenine (MeS-d-KYN), which was converted to blue-fluorescent 6-MeS-kynurenic acid (MeS-KYNA, λex… read more here.
Keywords: acid oxidase; dao; activity; amino acid ... See more keywords
Discovery of a Novel Class of d-Amino Acid Oxidase Inhibitors Using the Schrödinger Computational Platform.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00118
Abstract: d-Serine is a coagonist of the N-methyl d-aspartate (NMDA) receptor, a key excitatory neurotransmitter receptor. In the brain, d-serine is synthesized from its l-isomer by serine racemase and is metabolized by the D-amino acid oxidase… read more here.
Keywords: class; acid oxidase; amino acid; dinger computational ... See more keywords
Imine Synthesis by Engineered d-Amino Acid Oxidase from Porcine Kidney
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DOI: 10.1021/acsomega.4c09160
Abstract: Various symmetric and asymmetric imines were synthesized using the novel amine oxidase, obtained as variants of d-amino acid oxidase (pkDAO) from porcine kidney (Y228L/R283G) and (I230A/R283G). Active primary imines produced as intermediates in the oxidation… read more here.
Keywords: porcine kidney; oxidase; imine synthesis; synthesis ... See more keywords
CR-LAAO, an L-amino acid oxidase from Calloselasma rhodostoma venom, as a potential tool for developing novel immunotherapeutic strategies against cancer
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep42673
Abstract: L-amino acid oxidases from snake venoms have been described to possess various biological functions. In this study, we investigated the inflammatory responses induced in vivo and in vitro by CR-LAAO, an L-amino acid oxidase isolated… read more here.
Keywords: acid oxidase; amino; amino acid; calloselasma rhodostoma ... See more keywords
Involvement of d‐amino acid oxidase in cerebral ischaemia induced by transient occlusion of the middle cerebral artery in mice
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14764
Abstract: d‐Amino acid oxidase (DAAO) is a flavine adenine dinucleotide‐containing flavoenzyme and specifically catalyses oxidative deamination of d‐amino acids. This study aimed to explore the association between increased cerebral DAAO expression or enzymic activity and the… read more here.
Keywords: acid oxidase; amino; amino acid; cerebral ischaemia ... See more keywords
D-amino acid oxidase as a chemogenetic tool for spatiotemporally controlled hydrogen peroxide production: The oxygen connection.
Sign Up to like & getrecommendations! Published in 2025 at "British journal of pharmacology"
DOI: 10.1111/bph.70046
Abstract: BACKGROUND AND PURPOSE D-amino acid oxidase (DAO) has been developed as a chemogenetic tool, to precisely manipulate redox levels in tissues and cells by generating H2O2 in the presence of D-amino acids. The enzyme's significant… read more here.
Keywords: dao; oxygen; chemogenetic tool; amino acid ... See more keywords