HRD1 inhibits fatty acid oxidation and tumorigenesis by ubiquitinating CPT2 in triple‐negative breast cancer
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12856
Abstract: Dependence on glutamine and acceleration of fatty acid oxidation (FAO) are both metabolic characteristics of triple‐negative breast cancer (TNBC). With the rapid growth of tumors, accelerated glutamine catabolism depletes local glutamine, resulting in glutamine deficiency.… read more here.
Keywords: negative breast; hrd1; fatty acid; breast cancer ... See more keywords
Compromised hepatic mitochondrial fatty acid oxidation and reduced markers of mitochondrial turnover in human NAFLD
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32324
Abstract: NAFLD and its more‐advanced form, steatohepatitis (NASH), is associated with obesity and is an independent risk factor for cardiovascular, liver‐related, and all‐cause mortality. Available human data examining hepatic mitochondrial fatty acid oxidation (FAO) and hepatic… read more here.
Keywords: mitochondrial turnover; acid oxidation; hepatic mitochondrial; mitochondrial fatty ... See more keywords
Long‐chain fatty acid oxidation and respiratory complex I deficiencies distinguish Barth Syndrome from idiopathic pediatric cardiomyopathy
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12459
Abstract: Barth syndrome (BTHS) is an X‐linked disorder that results from mutations in the TAFAZZIN gene, which encodes a phospholipid transacylase responsible for generating the mature form of cardiolipin in inner mitochondrial membranes. BTHS patients develop… read more here.
Keywords: oxidation; acid oxidation; barth syndrome; long chain ... See more keywords
Evidence that Oxidative Disbalance and Mitochondrial Dysfunction are Involved in the Pathophysiology of Fatty Acid Oxidation Disorders.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-020-00955-7
Abstract: Mitochondrial fatty acid β-oxidation disorders (FAODs) are a group of about 20 diseases which are caused by specific mutations in genes that codify proteins or enzymes involved in the fatty acid transport and mitochondrial β-oxidation.… read more here.
Keywords: oxidation; fatty acid; evidence; oxidation disorders ... See more keywords
GCN5L1 controls renal lipotoxicity through regulating acetylation of fatty acid oxidation enzymes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Physiology and Biochemistry"
DOI: 10.1007/s13105-019-00711-6
Abstract: Dyslipidemia is a common risk factor of chronic kidney disease (CKD). Current notion suggests that insufficient intracellular fatty acid oxidation (FAO) and subsequently enhanced fatty acid esterification within renal resident cells, a process termed as… read more here.
Keywords: acetylation; lipotoxicity; fatty acid; renal lipotoxicity ... See more keywords
Three-dimensional hierarchical urchin-like PdCuPt nanoassembles with zigzag branches: A highly efficient and durable electrocatalyst for formic acid oxidation reaction
Sign Up to like & getrecommendations! Published in 2020 at "Applied Surface Science"
DOI: 10.1016/j.apsusc.2020.145480
Abstract: Abstract Hierarchically branched multi-metallic nanoassembles are promising catalysts extensively used in catalytic fields because of their unique structural features and multicompositions advantages. Herein, three-dimensional (3D) hierarchical zigzag-branched urchin-like PdCuPt superstructures (HZBUS) were prepared by a… read more here.
Keywords: three dimensional; dimensional hierarchical; urchin like; formic acid ... See more keywords
MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid β-Oxidation
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.05.058
Abstract: SUMMARY Micropeptide regulator of β-oxidation (MOXI) is a conserved muscle-enriched protein encoded by an RNA transcript misannotated as non-coding. MOXI localizes to the inner mitochondrial membrane where it associates with the mitochondrial trifunctional protein, an… read more here.
Keywords: oxidation; oxidation moxi; fatty acid; moxi ... See more keywords
High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109212
Abstract: SUMMARY Obesity is an established risk factor for cancer in many tissues. In the mammalian intestine, a pro-obesity high-fat diet (HFD) promotes regeneration and tumorigenesis by enhancing intestinal stem cell (ISC) numbers, proliferation, and function.… read more here.
Keywords: fat diet; fatty acid; diet activated; high fat ... See more keywords
Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.06.002
Abstract: T cell subsets including effector (Teff), regulatory (Treg), and memory (Tmem) cells are characterized by distinct metabolic profiles that influence their differentiation and function. Previous research suggests that engagement of long-chain fatty acid oxidation (LC-FAO)… read more here.
Keywords: fatty acid; cpt1a; independent cpt1a; cell ... See more keywords
Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.09.003
Abstract: Dietary sugars, fructose and glucose, promote hepatic de novo lipogenesis and modify the effects of a high-fat diet (HFD) on the development of insulin resistance. Here, we show that fructose and glucose supplementation of an… read more here.
Keywords: mitochondrial proteins; fructose glucose; fatty acid; dietary sugars ... See more keywords
Influence of the formulation of catalysts deposited on cordierite monoliths for acetic acid oxidation
Sign Up to like & getrecommendations! Published in 2017 at "Comptes Rendus Chimie"
DOI: 10.1016/j.crci.2017.08.004
Abstract: Abstract Monolithic catalysts are prepared by washcoating cordierite monoliths with different sols (Pt/Al2O3, Pt/CeO2, Pt/ZrO2, Pt/Al2O3 CeO2, Pt/Al2O3 ZrO2, and Pt/CeO2 ZrO2). These sols are prepared by a sol–gel process and characterized by specific surface… read more here.
Keywords: microscopy; cordierite monoliths; influence; acetic acid ... See more keywords