Identification of Disease-Specific Single Amino Acid Polymorphisms Using a Simple Random Forest at Protein-level
Sign Up to like & getrecommendations! Published in 2021 at "Current Bioinformatics"
DOI: 10.2174/1574893616666210825094751
Abstract: The number of human genetic variants deposited into publicly available databases has been increasing exponentially. Among these variants, non-synonymous single nucleotide polymorphisms (nsSNPs), also known as single amino acid polymorphisms (SAPs), have been demonstrated to… read more here.
Keywords: protein; amino acid; disease; random forest ... See more keywords
Amino acid polymorphisms in human histocompatibility leukocyte antigen class II and proinsulin epitope have impacts on type 1 diabetes mellitus induced by immune-checkpoint inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1165004
Abstract: Introduction Immune-checkpoint inhibitors are effective in various advanced cancers. Type 1 diabetes mellitus induced by them (ICI-T1DM) is a serious complication requiring prompt insulin treatment, but the immunological mechanism behind it is unclear. Methods We… read more here.
Keywords: acid polymorphisms; ici t1dm; proinsulin epitope; amino acid ... See more keywords