A Mitochondria-Targeted Phenylbutyric Acid Prodrug Confers Drastically Improved Anticancer Activities.
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DOI: 10.1021/acs.jmedchem.2c00640
Abstract: Phenylbutyric acid (PBA) has been reported as a dual inhibitor of pyruvate dehydrogenase kinases (PDKs) and histone deacetylases (HDACs), exhibiting anticancer effects. However, the low membrane permeability and poor cellular uptake limit its access to… read more here.
Keywords: anticancer activities; mitochondria targeted; acid prodrug; targeted phenylbutyric ... See more keywords