Orotic acid protects pancreatic β cell by p53 inactivation in diabetic mouse model.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.10.060
Abstract: Impairment of pancreatic β cells is a principal driver of the development of diabetes. Restoring normal insulin release from the β cells depends on the ATP produced by the intracellular mitochondria. In maintaining mitochondrial function,… read more here.
Keywords: cell; acid protects; p53; acid ... See more keywords
Valproic acid protects against MPP+-mediated neurotoxicity in SH-SY5Y Cells through autophagy
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2016.12.017
Abstract: Autophagy is a common physiological activity in cells. Studies show that dysregulation of autophagy is involved in the pathogenesis of Parkinson's disease (PD). As a commonly used anti-epileptic drug, valproic acid (VPA) has shown neuroprotective… read more here.
Keywords: protects mpp; vpa; acid protects; mpp mediated ... See more keywords