Evaluation of the Effects of Meal Type and Acid‐Reducing Agents on the Pharmacokinetics of Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor Agonist
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DOI: 10.1002/cpdd.1384
Abstract: Cilofexor is a nonsteroidal farnesoid X receptor agonist being developed in combination with firsocostat/semaglutide for the treatment of nonalcoholic steatohepatitis. This phase 1 study evaluated the effects of food and acid‐reducing agents (ARAs) on the… read more here.
Keywords: nonsteroidal farnesoid; fasting conditions; evaluated effects; receptor agonist ... See more keywords
Effect of Food Intake or Coadministration With an Acid‐Reducing Agent on Lenacapavir Pharmacokinetics Following Oral Administration
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DOI: 10.1002/cpdd.1513
Abstract: Lenacapavir is a potent, long‐acting HIV‐1 capsid inhibitor used in combination with other antiretrovirals to treat HIV‐1 infection. The pharmacokinetics of orally administered drugs may be affected by food intake or coadministration of acid‐reducing agents… read more here.
Keywords: food intake; food; intake coadministration; coadministration acid ... See more keywords
Should the Use of Acid Reducing Agents in Conjunction with Ribociclib be Avoided? An Integrated QbD Approach for Assessment of pH-Mediated Interaction.
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DOI: 10.1093/chromsci/bmac084
Abstract: The objective of the study was to evaluate the possible pH-dependent interaction of ribociclib succinate with acid-reducing agents, which are concomitantly administered as supportive care medicines in cancer. Quality by Design-based analytical method development for… read more here.
Keywords: interaction; ribociclib succinate; acid reducing; ribociclib ... See more keywords
The Synthesis and Stability Study of Silver Nanoparticles Prepared by Using p -Aminobenzoic Acid as Reducing and Stabilizing Agent
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DOI: 10.22146/ijc.29312
Abstract: A study to examine the performance of p-aminobenzoic acid as both reducing agent for silver nitrate to silver nanoparticles (AgNPs) and stabilizing agent for the formed AgNPs has been done. The synthesis of AgNPs was… read more here.
Keywords: aminobenzoic; aminobenzoic acid; silver; acid reducing ... See more keywords