Homology modeling and site-directed mutagenesis identify amino acid residues underlying the substrate selection mechanism of human monocarboxylate transporters 1 (hMCT1) and 4 (hMCT4)
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03151-z
Abstract: Human monocarboxylate transporters (hMCTs/SLC16As) mediate the transport of monocarboxylic compounds across plasma membranes. Among the hMCTs, hMCT1 and hMCT4 are expressed in various tissues, and transport substrates involved in energy metabolism. Both transporters mediate l-lactate… read more here.
Keywords: human monocarboxylate; acid residues; amino acid; hmct1 hmct4 ... See more keywords
Natively oxidized amino acid residues in the spinach cytochrome b6f complex
Sign Up to like & getrecommendations! Published in 2018 at "Photosynthesis Research"
DOI: 10.1007/s11120-018-0485-0
Abstract: The cytochrome b6f complex of oxygenic photosynthesis produces substantial levels of reactive oxygen species (ROS). It has been observed that the ROS production rate by b6f is 10–20 fold higher than that observed for the… read more here.
Keywords: amino acid; b6f; cytochrome b6f; spinach cytochrome ... See more keywords
Activity modulation of the oligopeptidase B from Serratia proteamaculans by site-directed mutagenesis of amino acid residues surrounding catalytic triad histidine.
Sign Up to like & getrecommendations! Published in 2017 at "Biochimie"
DOI: 10.1016/j.biochi.2017.05.013
Abstract: Oligopeptidase B (OpdB; EC 3.4.21.83) is a trypsin-like peptidase belonging to the family of serine prolyl oligopeptidases; two-domain structure of the enzyme includes C-terminal peptidase catalytic domain and N-terminal seven-bladed β-propeller domain. Importance of the… read more here.
Keywords: serratia proteamaculans; amino acid; surrounding catalytic; catalytic triad ... See more keywords
Pyxinol bearing amino acid residues: Easily achievable and promising modulators of P-glycoprotein-mediated multidrug resistance.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113317
Abstract: The P-glycoprotein (Pgp) is a major transporter involved in multidrug resistance (MDR) of cancer cells leading to chemotherapy failure. In our previous study, we demonstrated that the amide derivatives of pyxinol are promising modulators against… read more here.
Keywords: amino acid; promising modulators; pyxinol; resistance ... See more keywords
Evaluation of NHS-Acetate and DEPC labelling for determination of solvent accessible amino acid residues in protein complexes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2020.103793
Abstract: The activity of most proteins and protein complexes relies on the formation of defined three-dimensional structures. The analysis of these arrangements is therefore key for understanding their function and regulation in the cell. Besides the… read more here.
Keywords: accessible amino; acid residues; solvent accessible; amino acid ... See more keywords
Oxidative Damage of Aliphatic Amino Acid Residues by the Environmental Pollutant NO3·: Impact of Water on the Reactivity.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental science & technology"
DOI: 10.1021/acs.est.2c00863
Abstract: The rate of oxidative damage of aliphatic amino acids and dipeptides by the environmental pollutant nitrate radical (NO3·) in an aqueous acidic environment was studied by laser flash photolysis. The reactivity dropped by a factor… read more here.
Keywords: amino acid; acid residues; aliphatic amino; reactivity ... See more keywords
An Orbitide from Ratibida columnifera Seed Containing 16 Amino Acid Residues.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.9b00111
Abstract: Cyclic peptides are abundant in plants and have attracted interest due to their bioactivity and potential as drug scaffolds. Orbitides are head-to-tail cyclic peptides that are ribosomally synthesized, post-translationally modified, and lack disulfide bonds. All… read more here.
Keywords: seed; acid residues; amino acid; ratibida columnifera ... See more keywords
Discovery of Dehydroamino Acid Residues in the Capsid and Matrix Structural Proteins of HIV-1.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.1c00867
Abstract: Human immunodeficiency virus type 1 (HIV-1) remains a deadly infectious disease despite existing antiretroviral therapies. A comprehensive understanding of the specific mechanisms of viral infectivity remains elusive and currently limits the development of new and… read more here.
Keywords: discovery dehydroamino; acid residues; dehydroamino acids; dehydroamino acid ... See more keywords
Investigation of major amino acid residues of anti-norfloxacin monoclonal antibodies responsible for binding with fluoroquinolones
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-96466-6
Abstract: It is important to understand the amino acid residues that govern the properties of the binding between antibodies and ligands. We studied the binding of two anti-norfloxacins, anti-nor 132 and anti-nor 155, and the fluoroquinolones… read more here.
Keywords: monoclonal antibodies; anti 132; acid residues; amino acid ... See more keywords
An Overview on Exploring Chemical Modifications of Aromatic Amino Acid Residues in Peptides
Sign Up to like & getrecommendations! Published in 2023 at "Synthesis"
DOI: 10.1055/a-2091-8062
Abstract: The chemical diversification of biomolecules set forth a significant area that constitutes an important intersection between chemistry and biology. Amino acids and peptides, are the fundamental building blocks of proteins, play an ubiquitous role in… read more here.
Keywords: acid residues; amino acid; aromatic amino; chemical modifications ... See more keywords
A coarse-grained model of the effective interaction for charged amino acid residues and its application to formation of GCN4-pLI tetramer
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Physics"
DOI: 10.1080/00268976.2017.1393574
Abstract: ABSTRACT We present a simple coarse-grained model of the effective interaction for charged amino acid residues, such as Glu and Lys, in a water solvent. The free-energy profile as a function of the distance between… read more here.
Keywords: charged amino; amino acid; coarse grained; acid residues ... See more keywords