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Published in 2019 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24481
Abstract: Transforming growth factor‐β1 (TGF‐β1) is an important member of multifunctional growth factor superfamily. It has been implicated in pain signaling, but little is known about the underlying mechanisms. Herein, we report that TGF‐β1 can exert…
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Keywords:
sensing ion;
tgf;
activity acid;
activity ... See more keywords
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2
Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25060
Abstract: Resveratrol can relieve pain under various pain conditions. One of the mechanisms of resveratrol analgesia is the regulation of ion channels. Acid‐sensing ion channels (ASICs) are expressed predominantly in nociceptive sensory neurons to detect changes…
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Keywords:
acid sensing;
resveratrol;
male rat;
sensing ion ... See more keywords
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Published in 2022 at "Synapse"
DOI: 10.1002/syn.22227
Abstract: Acid-sensing ion channels (ASICs) participate in synaptic transmission due to acidic content of synaptic vesicles, but their contribution in the postsynaptic currents is small. This stimulates attempts to find endogenous ASIC potentiators that could enhance…
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Keywords:
sensing ion;
glutamate potentiates;
acid sensing;
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Published in 2019 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2018.11.001
Abstract: Recent advances indicate that there is crosstalk between allergic disorders and nucleic acid sensing. Triggers that activate inflammatory mechanisms via nucleic acid sensors affect both allergic phenotypes and anti-viral responses, depending on the timing and…
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Keywords:
anti viral;
disorders nucleic;
sensing allergic;
allergic disorders ... See more keywords
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Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.02.027
Abstract: &NA; GMQ (2‐guanidine‐4‐methylquinazoline or N‐(4‐methyl‐2‐quinazolinyl)‐guanidine hydrochloride), an agonist of acid‐sensing ion channel type 3, has been increasingly used for in vivo studies of alternations in nociceptic behavior. In this study, we tried to investigate whether…
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Keywords:
channel;
ion;
agonist acid;
guanidine methylquinazoline ... See more keywords
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Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.09.001
Abstract: Despite the sequence homology between acid-sensing ion channels (ASICs) and epithelial sodium channel (ENaCs), these channel families display very different functional characteristics. Whereas ASICs are gated by protons and show a relatively low degree of…
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Keywords:
sensing ion;
ion channels;
ion;
pore ... See more keywords
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Published in 2019 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2018.11.021
Abstract: &NA; Every organism must adapt and respond appropriately to the source of nutrients available in its environment. Different mechanisms and pathways are involved in detecting the intracellular and extracellular levels of macronutrients including amino acids.…
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Keywords:
protein;
amino acid;
amino acids;
implications amino ... See more keywords
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Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.04.054
Abstract: AIMS The recent identification of acid sensing ion channels (ASICs) in vascular beds suggests their possible involvement in modulating vasomotor tone. Therefore, we investigated the gene expression profiles of ASIC subtypes in the middle cerebral…
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Keywords:
sensing ion;
ion channels;
vasomotor;
expression ... See more keywords
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Published in 2019 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2019.103614
Abstract: Helicobacter pylori is an important etiological factor involved in chronic gastritis, peptic ulcer, and gastric cancer. There are currently no optimal preventive or therapeutic interventions for H. pylori infection. H. pylori survives in the stomach…
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Keywords:
arss;
p06;
sensing domain;
acid sensing ... See more keywords
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Published in 2017 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2017.08.015
Abstract: Objective Hypothalamic tanycytes are glial cells that line the wall of the third ventricle and contact the cerebrospinal fluid (CSF). While they are known to detect glucose in the CSF we now show that tanycytes…
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Keywords:
hypothalamic tanycytes;
taste;
amino acid;
amino acids ... See more keywords
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Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.03.044
Abstract: The over-activation of N-methyl-D-aspartate receptors (NMDARs) is the main cause of neuronal death in brain ischemia. Both the NMDAR and the Acid-sensing ion channel 1a (ASIC1a) are present in the postsynaptic membrane of the central…
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Keywords:
sensing ion;
nr1 nr2a;
asic1a;
ion channel ... See more keywords