TGF‐β1 enhances the activity of acid‐sensing ion channel in rat primary sensory neurons
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24481
Abstract: Transforming growth factor‐β1 (TGF‐β1) is an important member of multifunctional growth factor superfamily. It has been implicated in pain signaling, but little is known about the underlying mechanisms. Herein, we report that TGF‐β1 can exert… read more here.
Keywords: sensing ion; tgf; activity acid; activity ... See more keywords
Resveratrol inhibits the activity of acid‐sensing ion channels in male rat dorsal root ganglion neurons
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25060
Abstract: Resveratrol can relieve pain under various pain conditions. One of the mechanisms of resveratrol analgesia is the regulation of ion channels. Acid‐sensing ion channels (ASICs) are expressed predominantly in nociceptive sensory neurons to detect changes… read more here.
Keywords: acid sensing; resveratrol; male rat; sensing ion ... See more keywords
Glutamate potentiates heterologously expressed homomeric acid-sensing ion channel 1a.
Sign Up to like & getrecommendations! Published in 2022 at "Synapse"
DOI: 10.1002/syn.22227
Abstract: Acid-sensing ion channels (ASICs) participate in synaptic transmission due to acidic content of synaptic vesicles, but their contribution in the postsynaptic currents is small. This stimulates attempts to find endogenous ASIC potentiators that could enhance… read more here.
Keywords: sensing ion; glutamate potentiates; acid sensing;
Nucleic Acid Sensing in Allergic Disorders.
Sign Up to like & getrecommendations! Published in 2019 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2018.11.001
Abstract: Recent advances indicate that there is crosstalk between allergic disorders and nucleic acid sensing. Triggers that activate inflammatory mechanisms via nucleic acid sensors affect both allergic phenotypes and anti-viral responses, depending on the timing and… read more here.
Keywords: anti viral; disorders nucleic; sensing allergic; allergic disorders ... See more keywords
Multiple regulatory actions of 2‐guanidine‐4‐methylquinazoline (GMQ), an agonist of acid‐sensing ion channel type 3, on ionic currents in pituitary GH3 cells and in olfactory sensory (Rolf B1.T) neurons
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.02.027
Abstract: &NA; GMQ (2‐guanidine‐4‐methylquinazoline or N‐(4‐methyl‐2‐quinazolinyl)‐guanidine hydrochloride), an agonist of acid‐sensing ion channel type 3, has been increasingly used for in vivo studies of alternations in nociceptic behavior. In this study, we tried to investigate whether… read more here.
Keywords: channel; ion; agonist acid; guanidine methylquinazoline ... See more keywords
Evolutionarily Conserved Interactions within the Pore Domain of Acid-Sensing Ion Channels.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.09.001
Abstract: Despite the sequence homology between acid-sensing ion channels (ASICs) and epithelial sodium channel (ENaCs), these channel families display very different functional characteristics. Whereas ASICs are gated by protons and show a relatively low degree of… read more here.
Keywords: sensing ion; ion channels; ion; pore ... See more keywords
Implications of amino acid sensing and dietary protein to the aging process
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2018.11.021
Abstract: &NA; Every organism must adapt and respond appropriately to the source of nutrients available in its environment. Different mechanisms and pathways are involved in detecting the intracellular and extracellular levels of macronutrients including amino acids.… read more here.
Keywords: protein; amino acid; amino acids; implications amino ... See more keywords
Acid sensing ion channels in rat cerebral arteries: Probing the expression pattern and vasomotor activity.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.04.054
Abstract: AIMS The recent identification of acid sensing ion channels (ASICs) in vascular beds suggests their possible involvement in modulating vasomotor tone. Therefore, we investigated the gene expression profiles of ASIC subtypes in the middle cerebral… read more here.
Keywords: sensing ion; ion channels; vasomotor; expression ... See more keywords
Panning using a phage-displayed random peptide library to identify peptides that antagonize the Helicobacter pylori ArsS acid-sensing domain.
Sign Up to like & getrecommendations! Published in 2019 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2019.103614
Abstract: Helicobacter pylori is an important etiological factor involved in chronic gastritis, peptic ulcer, and gastric cancer. There are currently no optimal preventive or therapeutic interventions for H. pylori infection. H. pylori survives in the stomach… read more here.
Keywords: arss; p06; sensing domain; acid sensing ... See more keywords
Amino acid sensing in hypothalamic tanycytes via umami taste receptors
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2017.08.015
Abstract: Objective Hypothalamic tanycytes are glial cells that line the wall of the third ventricle and contact the cerebrospinal fluid (CSF). While they are known to detect glucose in the CSF we now show that tanycytes… read more here.
Keywords: hypothalamic tanycytes; taste; amino acid; amino acids ... See more keywords
Acid-Sensing Ion Channel 1a Modulates NMDA Receptor Function Through Targeting NR1/NR2A/NR2B Triheteromeric Receptors
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.03.044
Abstract: The over-activation of N-methyl-D-aspartate receptors (NMDARs) is the main cause of neuronal death in brain ischemia. Both the NMDAR and the Acid-sensing ion channel 1a (ASIC1a) are present in the postsynaptic membrane of the central… read more here.
Keywords: sensing ion; nr1 nr2a; asic1a; ion channel ... See more keywords