Integrated continuous biomanufacturing on pilot scale for acid-sensitive monoclonal antibodies.
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28120
Abstract: In this study, we demonstrated the first, to our knowledge, integrated continuous bioprocess (ICB) designed for the production of acid-sensitive monoclonal antibodies, prone to aggregate at low pH, on pilot scale. A high cell density… read more here.
Keywords: pilot scale; acid sensitive; monoclonal antibodies; integrated continuous ... See more keywords
Acid-sensitive and L61-crosslinked hyaluronic acid nanogels for overcoming tumor drug-resistance.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.08.004
Abstract: Low intracellular drugs concentration is one of the main representations of multidrug resistance (MDR), which often results in a weak or failed chemotherapy on cancer treatment. Herein, an acid-sensitive and pluronic L61-linked hyaluronic acid nanogels… read more here.
Keywords: l61; acid nanogels; resistance; hyaluronic acid ... See more keywords
Acid-sensitive auxiliary assisted atypical diubiquitin synthesis exploiting thiol-ene coupling
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.151123
Abstract: Abstract Atypical ubiquitin (Ub) chains are generally involved in intracellular physiological processes, while the molecular mechanisms underlying their regulation remain unclear. In this work, we report an acid-sensitive auxiliary group based bifunctional handle that can… read more here.
Keywords: sensitive auxiliary; thiol ene; assisted atypical; ene coupling ... See more keywords
Water- and Acid-Sensitive Cu2O@Cu-MOF Nano Sustained-Release Capsules with Superior Antifouling Behaviors.
Sign Up to like & getrecommendations! Published in 2021 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c18288
Abstract: Marine biofouling is one of the technical bottlenecks restricting the development of the global marine economy. Among the commercial self-polishing antifouling coatings, cuprous oxide is an irreplaceable component because of its efficiency and broad-spectrum antibacterial… read more here.
Keywords: cu2o; release; acid sensitive; mof ... See more keywords
Acid-Sensitive PEG-Removable Nanoscale Liposomes for Delivery of Doxorubicin in A549/ADR Therapy
Sign Up to like & getrecommendations! Published in 2023 at "New Journal of Chemistry"
DOI: 10.1039/d3nj01764h
Abstract: Polyethylene glycol (PEG) which can impart long cycling performance to drug carriers, has been commonly used for drug carrier modification. However, PEG modification impedes cellular uptake of drug carriers and... read more here.
Keywords: removable nanoscale; sensitive peg; liposomes delivery; peg removable ... See more keywords
A9357 The genetic polymorphisms of TWIK-related acid-sensitive K+ channel-3 (TASK-3) were associated with obstructive sleep apnea in patients with hypertension
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000548216.53388.81
Abstract: Objectives: TWIK-related acid-sensitive K+ channel-3 was reported to be a risk factor for OSA in animal models. The present study aimed to evaluate the relationship between human TASK-3 gene polymorphisms and obstructive sleep apnea in… read more here.
Keywords: twik related; related acid; task; hypertension ... See more keywords
Tandem pore domain acid-sensitive K channel 3 (TASK-3) regulates visual sensitivity in healthy and aging retina
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn8785
Abstract: Retinal ganglion cells (RGCs) not only collect but also integrate visual signals and send them from the retina to the brain. The mechanisms underlying the RGC integration of synaptic activity within retinal circuits have not… read more here.
Keywords: sensitivity; tandem pore; task; pore domain ... See more keywords