A Nucleic Acid Sequence That is Catalytically Active in Both RNA and TNA Backbones.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00479
Abstract: Threose nucleic acid (TNA) is considered a potential RNA progenitor due to its chemical simplicity, base pairing property, and capability of folding into a functional tertiary structure. However, it is unknown whether the functional property… read more here.
Keywords: tna rna; tna; sequence catalytically; rna ... See more keywords
General strategies for using amino acid sequence data to guide biochemical investigation of protein function.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society transactions"
DOI: 10.1042/bst20220849
Abstract: The rapid increase of '-omics' data warrants the reconsideration of experimental strategies to investigate general protein function. Studying individual members of a protein family is likely insufficient to provide a complete mechanistic understanding of family… read more here.
Keywords: family; acid sequence; sequence; amino acid ... See more keywords
On the reliability and the limits of inference of amino acid sequence alignments
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DOI: 10.1093/bioinformatics/btac247
Abstract: Abstract Motivation Alignments are correspondences between sequences. How reliable are alignments of amino acid sequences of proteins, and what inferences about protein relationships can be drawn? Using techniques not previously applied to these questions, by… read more here.
Keywords: limits inference; sequence; acid sequence; amino acid ... See more keywords
HNOXPred: a web tool for the prediction of gas-sensing H-NOX proteins from amino acid sequence
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DOI: 10.1093/bioinformatics/btac571
Abstract: SUMMARY HNOXPred is a webserver for the prediction of gas sensing H-NOX proteins from amino acid sequence. Heme-Nitric oxide/Oxygen (H-NOX) proteins are gas sensing hemoproteins found in diverse organisms ranging from bacteria to eukaryotes. Recently,… read more here.
Keywords: gas sensing; nox proteins; acid sequence; amino acid ... See more keywords
A new marker sequence for systematics of medically important fungi based on amino acid sequence of the largest subunit of RNA polymerase I
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DOI: 10.1093/mmy/myw098
Abstract: &NA; Molecular evolution has dominated taxonomic studies for decades, replacing traditional methods for identification and classification. However, there is a need for better markers to resolve the problems that have limited their usefulness. In this… read more here.
Keywords: amino acid; largest subunit; systematics; subunit rna ... See more keywords
Variations in candidalysin amino acid sequence influence toxicity and host responses
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DOI: 10.1128/mbio.03351-23
Abstract: ABSTRACT Candida albicans causes millions of mucosal infections in humans annually. Hyphal overgrowth on mucosal surfaces is frequently associated with tissue damage caused by candidalysin, a secreted peptide toxin that destabilizes the plasma membrane of… read more here.
Keywords: candidalysin; candidalysin variants; ability; amino acid ... See more keywords
An improved nucleic acid sequence-based amplification method mediated by T4 gene 32 protein
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DOI: 10.1371/journal.pone.0265391
Abstract: The uptake of Nucleic Acid Sequence-Based Amplification (NASBA) for point of care testing may be hindered by a complexity in the workflow due the requirement of a thermal denaturation step to initiate the cyclic isothermal… read more here.
Keywords: amplification; acid sequence; nucleic acid; based amplification ... See more keywords
Optimizing the Amino Acid Sequences of Peptides and Improving Their Specificity of Binding to SH3 Domains of Target Proteins
Sign Up to like & getrecommendations! Published in 2017 at "Indian Journal of Pharmaceutical Education and Research"
DOI: 10.5530/ijper.51.1.7
Abstract: Introduction: It is always a crucial challenge in biotechnology to avoid promiscuous binding between an anticancer peptide and multiple SH3 domains, thus reducing potential toxic effects. In spite of a great deal of experimental efforts,… read more here.
Keywords: peptide; amino acid; sh3 domains; acid sequence ... See more keywords