EZH2 modulates retinoic acid signaling to ensure myotube formation during development
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14334
Abstract: Sequential differentiation of presomitic progenitors into myocytes and subsequently into myotubes and myofibers is essential for the myogenic differentiation program (MDP) crucial for muscle development. Signaling factors involved in MDP are polycomb repressive complex 2… read more here.
Keywords: myocyte differentiation; development; retinoic acid; differentiation ... See more keywords
Impairment of Retinoic Acid Signaling in Cornelia de Lange Syndrome Fibroblasts.
Sign Up to like & getrecommendations! Published in 2017 at "Birth defects research"
DOI: 10.1002/bdr2.1070
Abstract: BACKGROUND Cornelia de Lange syndrome (CdLS) is a rare genetic disorder affecting the neurodevelopment, gastrointestinal, musculoskeletal systems. CdLS is caused by mutations within NIPBL, SMC1A, SMC3, RAD21, and HDAC8 genes. These genes codify for the… read more here.
Keywords: cdls patients; lange syndrome; treatment; acid signaling ... See more keywords
Retinoic acid signaling regulates late stages of semicircular canal morphogenesis and otolith maintenance in the zebrafish inner ear
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Dynamics"
DOI: 10.1002/dvdy.510
Abstract: The vitamin A derivative all‐trans retinoic acid (RA) regulates early stages of inner ear development. As the early disruption of the RA pathway results in profound mispatterning of the developing inner ear, this confounds analyses… read more here.
Keywords: signaling regulates; inner ear; acid signaling; retinoic acid ... See more keywords
Retinoic acid signaling in vascular development
Sign Up to like & getrecommendations! Published in 2019 at "genesis"
DOI: 10.1002/dvg.23287
Abstract: Formation of the vasculature is an essential developmental process, delivering oxygen and nutrients to support cellular processes needed for tissue growth and maturation. Retinoic acid (RA) and its downstream signaling pathway is vital for normal… read more here.
Keywords: acid signaling; signaling vascular; vascular development; retinoic acid ... See more keywords
Roles of Retinoic Acid Signaling in Shaping the Neuronal Architecture of the Developing Amphioxus Nervous System
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0727-8
Abstract: The morphogen retinoic acid (RA) patterns vertebrate nervous systems and drives neurogenesis, but how these functions evolved remains elusive. Here, we show that RA signaling plays stage- and tissue-specific roles during the formation of neural… read more here.
Keywords: nervous system; acid signaling; retinoic acid; signaling shaping ... See more keywords
E-liquids and vanillin flavoring disrupts retinoic acid signaling and causes craniofacial defects in Xenopus embryos.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental biology"
DOI: 10.1016/j.ydbio.2021.09.004
Abstract: Environmental teratogens such as smoking are known risk factors for developmental disorders such as cleft palate. While smoking rates have declined, a new type of smoking, called vaping is on the rise. Vaping is the… read more here.
Keywords: xenopus embryos; craniofacial defects; acid signaling; embryos exposed ... See more keywords
Ferulic Acid: Signaling Pathways in Aging
Sign Up to like & getrecommendations! Published in 2023 at "Drug Research"
DOI: 10.1055/a-2061-7129
Abstract: Abstract The need for clinical remedies to the multiple age-related deficiencies in skin function brought on by extrinsic and intrinsic causes is increased by these demographic changes. Reactive oxygen species (ROS), mitochondrial deoxyribonucleic acid (mtDNA)… read more here.
Keywords: free radicals; pathways aging; acid; signaling pathways ... See more keywords
CK2 promotes jasmonic acid signaling response by phosphorylating MYC2 in Arabidopsis
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1213
Abstract: Abstract Jasmonic acid (JA) signaling plays a pivotal role in plant development and defense. MYC2 is a master transcription factor in JA signaling, and was found to be phosphorylated and negatively regulated by MAP kinase… read more here.
Keywords: myc2; ck2 promotes; ck2; jasmonic acid ... See more keywords
Bile acids as metabolic regulators: an update
Sign Up to like & getrecommendations! Published in 2023 at "Current Opinion in Gastroenterology"
DOI: 10.1097/mog.0000000000000934
Abstract: Purpose of review This review aims to provide a concise update on recent advances in understanding of the bile acid metabolism and signaling in health and diseases. Recent findings CYP2C70 has been identified as the… read more here.
Keywords: acids metabolic; bile acids; acid; metabolic regulators ... See more keywords
Molecular Physiology of Bile Acid Signaling in Health, Disease and Aging.
Sign Up to like & getrecommendations! Published in 2020 at "Physiological reviews"
DOI: 10.1152/physrev.00049.2019
Abstract: Over the last two decades, bile acids (BAs) have become established as important signaling molecules that enable fine-tuned inter-tissue communication from the liver, their site of production, over the intestine, where they are modified by… read more here.
Keywords: signaling health; physiology bile; acid signaling; physiology ... See more keywords
Targeting S100A9–ALDH1A1–Retinoic Acid Signaling to Suppress Brain Relapse in EGFR-Mutant Lung Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Discovery"
DOI: 10.1158/2159-8290.cd-21-0910
Abstract: The S100A9–ALDH1A1–retinoic acid signaling pathway mediates osimertinib resistance and brain relapse in models of EGFR-mutant lung cancer. read more here.
Keywords: brain relapse; s100a9 aldh1a1; retinoic acid; aldh1a1 retinoic ... See more keywords