Acid sphingomyelinase (ASM) and COVID‐19: A review of the potential use of ASM inhibitors against SARS‐CoV‐2
Sign Up to like & getrecommendations! Published in 2023 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3789
Abstract: In the last 2 years, different pharmacological agents have been indicated as potential inhibitors of SARS‐CoV‐2 in vitro. Specifically, drugs termed as functional inhibitors of acid sphingomyelinase (FIASMAs) have proved to inhibit the SARS‐CoV‐2 replication… read more here.
Keywords: inhibitors sars; review; asm; sphingomyelinase asm ... See more keywords
Plasma membrane reorganization links acid sphingomyelinase/ceramide to p38 MAPK pathways in endothelial cells apoptosis.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.02.001
Abstract: The p38 MAPK signaling pathway is essential in the cellular response to stress stimuli, in particular in the endothelial cells that are major target of external stress. The importance of the bioactive sphingolipid ceramide generated… read more here.
Keywords: p38 mapk; acid sphingomyelinase; endothelial cells; apoptosis ... See more keywords
Novel Mutations in the SMPD1 Gene in Jordanian Children with Acid Sphingomyelinase Deficiency (Niemann-Pick Types A and B).
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.144683
Abstract: Acid sphingomyelinase (ASM) deficiency (ASMD) is a spectrum that includes Niemann-Pick disease (NPD) types A (NPD A) and B (NPD B). ASMD is characterized by intracellular accumulation of unesterified cholesterol and gangliosides within the endosomal-lysosomal… read more here.
Keywords: mutations smpd1; smpd1 gene; gene; acid sphingomyelinase ... See more keywords
Consensus recommendation for a diagnostic guideline for acid sphingomyelinase deficiency
Sign Up to like & getrecommendations! Published in 2017 at "Genetics in Medicine"
DOI: 10.1038/gim.2017.7
Abstract: Disclaimer:This diagnostic guideline is intended as an educational resource and represents the opinions of the authors, and is not representative of recommendations or policy of the American College of Medical Genetics and Genomics (ACMG). The… read more here.
Keywords: sphingomyelinase; diagnostic guideline; acid sphingomyelinase; sphingomyelinase deficiency ... See more keywords
Acid sphingomyelinase promotes SGK1-dependent vascular calcification.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical science"
DOI: 10.1042/cs20201122
Abstract: In chronic kidney disease (CKD), hyperphosphatemia is a key factor promoting medial vascular calcification, a common complication associated with cardiovascular events and high mortality. Vascular calcification involves osteo-/chondrogenic transdifferentiation of vascular smooth muscle cells (VSMCs),… read more here.
Keywords: sgk1 dependent; calcification; acid sphingomyelinase; vascular calcification ... See more keywords
Solving the secretory acid sphingomyelinase puzzle: Insights from lysosome‐mediated parasite invasion and plasma membrane repair
Sign Up to like & getrecommendations! Published in 2019 at "Cellular Microbiology"
DOI: 10.1111/cmi.13065
Abstract: Acid sphingomyelinase (ASM) is a lysosomal enzyme that cleaves the phosphorylcholine head group of sphingomyelin, generating ceramide. Recessive mutations in SMPD1, the gene encoding ASM, cause Niemann–Pick Disease Types A and B. These disorders are… read more here.
Keywords: parasite invasion; membrane; acid sphingomyelinase; plasma membrane ... See more keywords
Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/0008-5472.can-19-1527
Abstract: This study identifies secreted ASM and ceramide as paracrine factors enhancing intestinal epithelial dysfunction, revealing a previously unknown class of mediators of radiosensitivity. Ceramide-induced endothelial cell apoptosis boosts intestinal stem cell radiosensitivity. However, the molecular… read more here.
Keywords: radiation; dysfunction; ceramide; asm ceramide ... See more keywords
Altered Macrophage Function Associated with Crystalline Lung Inflammation in Acid Sphingomyelinase Deficiency.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2020-0229oc
Abstract: Deficiency of acid sphingomyelinase (ASM) causes the lysosomal storage Niemann-Pick disease (NPD). NPD type B patients may develop progressive interstitial lung disease with frequent respiratory infections. Although several investigations using the ASM deficient (ASMKO) mouse… read more here.
Keywords: lung; biology; deficiency; acid sphingomyelinase ... See more keywords
Acid sphingomyelinase promotes mitochondrial dysfunction due to glutamate-induced regulated necrosis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Lipid Research"
DOI: 10.1194/jlr.m080374
Abstract: Inhibiting the glutamate/cystine antiporter system xc−, a key antioxidant defense machinery in the CNS, could trigger a novel form of regulated necrotic cell death, ferroptosis. The underlying mechanisms of system xc−-dependent cell demise were elucidated… read more here.
Keywords: system; glutamate induced; sphingomyelinase promotes; glutamate ... See more keywords
Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of lipid research"
DOI: 10.1194/jlr.ra120000682
Abstract: Inhibition of acid sphingomyelinase (ASM), a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin into ceramide and phosphorylcholine, may serve as an investigational tool or a therapeutic intervention to control many diseases. Specific ASM inhibitors… read more here.
Keywords: characterization small; vitro; acid sphingomyelinase; arc39 ... See more keywords
Acid sphingomyelinase regulates the localization and trafficking of palmitoylated proteins
Sign Up to like & getrecommendations! Published in 2019 at "Biology Open"
DOI: 10.1242/bio.040311
Abstract: ABSTRACT In human, loss of acid sphingomyelinase (ASM/SMPD1) causes Niemann–Pick disease, type A. ASM hydrolyzes sphingomyelins to produce ceramides but protein targets of ASM remain largely unclear. Our mass spectrometry-based proteomic analyses have identified >100… read more here.
Keywords: plasma membrane; acid sphingomyelinase; palmitoylated proteins; regulates localization ... See more keywords