GCN2 kinase-mediated upregulation of ubiquitin C maintains intracellular glutamine level and tRNAGln (CUG) charging under amino acid starvation.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14628
Abstract: Each tRNA is aminoacylated (charged) with a genetic codon-specific amino acid. It remains unclear what factors are associated with tRNA charging and how tRNA charging is maintained. By using the individual tRNA acylation PCR (i-tRAP)… read more here.
Keywords: glutamine level; acid starvation; cug; amino acid ... See more keywords
The sharp phase of respiratory inhibition during amino acid starvation in Escherichia coli is RelA-dependent and associated with regulation of ATP synthase activity.
Sign Up to like & getrecommendations! Published in 2018 at "Research in microbiology"
DOI: 10.1016/j.resmic.2018.02.003
Abstract: Amino acid starvation causes an RelA-dependent increase in the regulatory nucleotide (p)ppGpp that leads to pleiotropic changes in Escherichia coli metabolism, but the role of (p)ppGpp in regulation of respiration remains unclear. Here we demonstrate… read more here.
Keywords: atp synthase; amino acid; acid starvation; inhibition ... See more keywords
Transfer RNA is highly unstable during early amino acid starvation in Escherichia coli
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DOI: 10.1093/nar/gkw1169
Abstract: Due to its long half-life compared to messenger RNA, bacterial transfer RNA is known as stable RNA. Here, we show that tRNAs become highly unstable as part of Escherichia coli's response to amino acid starvation.… read more here.
Keywords: transfer rna; amino; amino acid; acid starvation ... See more keywords
Sensing amino acid starvation
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DOI: 10.1126/science.367.6474.159-d
Abstract: Gene Expression Most Gram-positive bacteria have genetic switches that regulate the expression of genes involved in amino acid synthesis. These switches are sequences called T-boxes that occur before the coding sequence in the relevant messenger… read more here.
Keywords: expression; amino acid; acid starvation; sensing amino ... See more keywords
Amino Acid Starvation-Induced Glutamine Accumulation Enhances Pneumococcal Survival
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DOI: 10.1128/msphere.00625-22
Abstract: Bacteria are known to cope with amino acid starvation by halting growth and prolonging survival via the stringent response signaling system. Previous investigations have allowed us to understand how the stringent response regulates many aspects… read more here.
Keywords: acid starvation; accumulation; starvation; amino acid ... See more keywords
Amino acid starvation sensing dampens IL-1β production by activating riboclustering and autophagy
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DOI: 10.1371/journal.pbio.2005317
Abstract: Activation of the amino acid starvation response (AAR) increases lifespan and acute stress resistance as well as regulates inflammation. However, the underlying mechanisms remain unclear. Here, we show that activation of AAR pharmacologically by Halofuginone… read more here.
Keywords: amino acid; production; activation; acid starvation ... See more keywords
Amino acid starvation‐induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearance
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DOI: 10.15252/embr.202153373
Abstract: Mammalian cells utilize Akt‐dependent signaling to deploy intracellular Glut4 toward cell surface to facilitate glucose uptake. Low‐density lipoprotein receptor (LDLR) is the cargo receptor mediating endocytosis of apolipoprotein B‐containing lipoproteins. However, signaling‐controlled regulation of intracellular… read more here.
Keywords: acid starvation; amino acid; endocytosis; ldlr trafficking ... See more keywords
Targeting the Proline–Glutamine–Asparagine–Arginine Metabolic Axis in Amino Acid Starvation Cancer Therapy
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DOI: 10.3390/ph14010072
Abstract: Proline, glutamine, asparagine, and arginine are conditionally non-essential amino acids that can be produced in our body. However, they are essential for the growth of highly proliferative cells such as cancers. Many cancers express reduced… read more here.
Keywords: amino; amino acid; amino acids; starvation ... See more keywords