Cytochrome P450 2C9 polymorphism: Effect of amino acid substitutions on protein flexibility in the presence of tamoxifen
Sign Up to like & getrecommendations! Published in 2020 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2019.107166
Abstract: Tamoxifen is a prodrug and cytochrome P450 2C9 (CYP2C9) has a significant role in the formation of a therapeutically more potent metabolite (4-hydroxytamoxifen) than tamoxifen. Since CYP2C9 exhibits genetic polymorphism, it may contribute to different… read more here.
Keywords: amino acid; presence tamoxifen; tamoxifen; biology ... See more keywords
A one-step real-time RT-PCR assay for simultaneous typing of SARS-CoV-2 mutations associated with the E484K and N501Y spike protein amino-acid substitutions
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virological Methods"
DOI: 10.1016/j.jviromet.2021.114242
Abstract: The emergence of SARS-CoV-2 mutations resulting in the S protein amino-acid substitutions N501Y and E484K, which have been associated with enhanced transmissibility and immune escape, respectively, necessitates immediate actions, for which their rapid identification is… read more here.
Keywords: amino acid; cov mutations; protein amino; sars cov ... See more keywords
Amino acid substitutions in VP2, VP1, and 2C attenuate a Coxsackievirus A16 in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2020.104603
Abstract: Coxsackievirus A16 (CVA16) is one of the major etiological agents of hand, foot and mouth disease (HFMD), a common acute infectious disease affecting infants and young children. Severe symptoms of the central nervous system may… read more here.
Keywords: amino acid; coxsackievirus a16; vp1; mice ... See more keywords
Rapid acquisition adaptive amino acid substitutions involved in the virulence enhancement of an H1N2 avian influenza virus in mice.
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2017.06.009
Abstract: Although H1N2 avian influenza virus (AIV) only infect birds, documented cases of swine infection with H1N2 influenza viruses suggest this subtype AIV may pose a potential threat to mammals. Here, we generated mouse-adapted variants of… read more here.
Keywords: amino acid; virulence; h1n2; influenza ... See more keywords
Pleiotropic effects of hemagglutinin amino acid substitutions of influenza A(H1N1)pdm09 virus escape mutants.
Sign Up to like & getrecommendations! Published in 2018 at "Virus research"
DOI: 10.1016/j.virusres.2018.05.002
Abstract: In the present study we assessed pleiotropic characteristics of the antibody-selected mutations. We investigated pH optimum of fusion, temperatures of HA heat inactivation, in vivo and in vitro replication kinetics, and connectivity with panel of… read more here.
Keywords: amino acid; pleiotropic effects; escape mutants; acid substitutions ... See more keywords
Systematic d-Amino Acid Substitutions to Control Peptide and Hydrogel Degradation in Cellular Microenvironments.
Sign Up to like & getrecommendations! Published in 2023 at "ACS macro letters"
DOI: 10.1021/acsmacrolett.3c00144
Abstract: Enzymatically degradable peptides are commonly used as linkers within hydrogels for biological applications; however, controlling the degradation of these engineered peptides with different contexts and cell types can prove challenging. In this work, we systematically… read more here.
Keywords: acid substitutions; systematic amino; peptide; amino acid ... See more keywords
Core amino acid substitutions in HCV-3a isolates from Pakistan and opportunities for multi-epitopic vaccines
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1850353
Abstract: Abstract Hepatitis C virus (HCV), which infected 71 million worldwide and about 5%–6% are from Pakistan, is an ssRNA virus, responsible for end‐stage liver disease. To date, no effective therapy is available to cure this… read more here.
Keywords: core amino; core; substitutions hcv; acid substitutions ... See more keywords
Three amino acid substitutions contributing to thermostability of phosphoglucose isomerase in the Glanville fritillary butterfly.
Sign Up to like & getrecommendations! Published in 2022 at "Insect science"
DOI: 10.1111/1744-7917.13145
Abstract: Temperature is one of the most important environmental factors that affect organisms, especially ectotherms, due to its effects on protein stability. Understanding the general rules that govern thermostability changes in proteins to adapt high-temperature environments… read more here.
Keywords: acid substitutions; phosphoglucose isomerase; pgi; thermostability ... See more keywords
Congenital coagulation factor X deficiency: Genetic analysis of five patients and functional characterization of mutant factor X proteins
Sign Up to like & getrecommendations! Published in 2018 at "Haemophilia"
DOI: 10.1111/hae.13606
Abstract: Congenital factor X (FX) deficiency is a rare bleeding disorder that is inherited as an autosomal recessive trait. In this study, a genetic analysis of the FX gene was performed in five families with this… read more here.
Keywords: amino acid; acid substitutions; factor deficiency; factor ... See more keywords
Impact of Amino Acid Substitutions in Region II and Helix K of Herpes Simplex Virus 1 and Human Cytomegalovirus DNA Polymerases on Resistance to Foscarnet
Sign Up to like & getrecommendations! Published in 2021 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00390-21
Abstract: Amino acid substitutions conferring resistance to foscarnet (PFA) to herpes simplex virus 1 (HSV-1) and human cytomegalovirus (HCMV) are located in the genes UL30 and UL54, respectively, encoding the DNA polymerase (pol). In this study,… read more here.
Keywords: dna; region; herpes simplex; acid substitutions ... See more keywords
Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 Spike
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01162-22
Abstract: In a span of less than 3 years since the declaration of the coronavirus pandemic, numerous SARS-CoV-2 variants of concern have emerged all around the globe, fueling a surge in the number of cases and deaths… read more here.
Keywords: acid substitutions; amino acid; sars cov; concern ... See more keywords