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   Articles with "acid synthase" as a keyword



A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes

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recommendations! Published in 2017 at "FEBS Letters"

DOI: 10.1002/1873-3468.12620

Abstract: Fatty acid synthase (Fasn) is a key component of energy metabolism that is dynamically induced by food intake. Although extensive studies have revealed a number of transcription factors involved in the fasting/refeeding transition of Fasn… read more here.

Keywords: acid synthase; fatty acid; nuclear factor; refeeding response ... See more keywords

Delta-aminolevulinic acid synthase 2 expression in combination with iron as modifiers of disease severity in erythropoietic protoporphyria.

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recommendations! Published in 2019 at "Molecular genetics and metabolism"

DOI: 10.1016/j.ymgme.2019.04.013

Abstract: Deficiency in ferrochelatase (FECH), the last enzyme in the heme biosynthetic pathway, leads to an accumulation of protoporphyrin IX (PPIX) that causes a severely painful phototoxic reaction of the skin in patients with erythropoietic protoporphyria… read more here.

Keywords: erythropoietic protoporphyria; aminolevulinic acid; acid synthase; epp patients ... See more keywords

NeuNAc oxime: A slow-binding and effectively irreversible inhibitor of the sialic acid synthase NeuB.

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recommendations! Published in 2019 at "Biochemistry"

DOI: 10.1021/acs.biochem.9b00654

Abstract: NeuB is a bacterial sialic acid synthase used by neuroinvasive bacteria to synthesize N-acetylneuraminate (NeuNAc), helping them to evade the host immune system. NeuNAc oxime is a potent slow-binding NeuB inhibitor. It dissociated too slowly… read more here.

Keywords: inhibitor; binding; acid synthase; effectively irreversible ... See more keywords

Structure-Based Discovery of Lipoteichoic Acid Synthase Inhibitors

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recommendations! Published in 2022 at "Journal of Chemical Information and Modeling"

DOI: 10.1021/acs.jcim.2c00300

Abstract: Lipoteichoic acid synthase (LtaS) is a key enzyme for the cell wall biosynthesis of Gram-positive bacteria. Gram-positive bacteria that lack lipoteichoic acid (LTA) exhibit impaired cell division and growth defects. Thus, LtaS appears to be… read more here.

Keywords: structure; acid synthase; compound 1771; lipoteichoic acid ... See more keywords

High-Speed Atomic Force Microscopy Visualization of the Dynamics of the Multienzyme Fatty Acid Synthase.

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recommendations! Published in 2017 at "ACS nano"

DOI: 10.1021/acsnano.7b04216

Abstract: Multienzymes, such as the protein metazoan fatty acid synthase (FAS), are giant and highly dynamic molecular machines for critical biosynthetic processes. The molecular architecture of FAS was elucidated by static high-resolution crystallographic analysis, while electron… read more here.

Keywords: speed atomic; microscopy; fatty acid; acid synthase ... See more keywords

Snapshots of acyl carrier protein shuttling in human fatty acid synthase

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recommendations! Published in 2025 at "Nature"

DOI: 10.1038/s41586-025-08587-x

Abstract: The mammalian fatty acid synthase (FASN) enzyme is a dynamic multienzyme that belongs to the megasynthase family. In mammals, a single gene encodes six catalytically active domains and a flexibly tethered acyl carrier protein (ACP)… read more here.

Keywords: acid synthase; acyl carrier; carrier protein; fatty acid ... See more keywords

Structural dynamics of human fatty acid synthase in the condensing cycle

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recommendations! Published in 2025 at "Nature"

DOI: 10.1038/s41586-025-08782-w

Abstract: Long-chain fatty acids are the building blocks of fat in human bodies. In mammals, fatty acid synthase (FASN) contains multiple enzymatic domains to catalyse all chemical reactions needed for de novo fatty acid synthesis1. Although… read more here.

Keywords: acid synthase; structural dynamics; fatty acid; condensing cycle ... See more keywords
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In silico drug repurposing for filarial infection predicts nilotinib and paritaprevir as potential inhibitors of the Wolbachia 5′-aminolevulinic acid synthase

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-87976-4

Abstract: Filarial infections affect millions of individuals and are responsible for some notorious disabilities. Current treatment options involve repeated mass drug administrations, which have been met with several challenges despite some successes. Administration of doxycycline, an… read more here.

Keywords: silico drug; drug repurposing; aminolevulinic acid; drug ... See more keywords

Targeting fatty acid synthase reduces aortic atherosclerosis and inflammation

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recommendations! Published in 2025 at "Communications Biology"

DOI: 10.1038/s42003-025-07656-1

Abstract: Fatty acid synthase (FAS) is predominantly expressed in the liver and adipose tissue. It plays vital roles in de novo synthesis of saturated fatty acids and regulates insulin sensitivity. We previously demonstrated that serum circulating… read more here.

Keywords: acid synthase; aortic atherosclerosis; foam cell; fatty acid ... See more keywords

Acetyl-CoA-mediated autoacetylation of fatty acid synthase as a metabolic switch of de novo lipogenesis in Drosophila

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2212220119

Abstract: Significance Metabolic homeostasis plays a vital role in animal growth. Here, we show that acetylation of fatty acid synthase (FASN) contributes to de novolipogenesis during fly development. Although acetylation of most proteins is catalyzed by… read more here.

Keywords: acetyl coa; acid synthase; coa mediated; coa ... See more keywords

Improvement of valine and isobutanol production in sake yeast by Ala31Thr substitution in the regulatory subunit of acetohydroxy acid synthase.

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recommendations! Published in 2023 at "FEMS yeast research"

DOI: 10.1093/femsyr/foad012

Abstract: The fruit-like aroma of two valine-derived volatiles, isobutanol and isobutyl acetate, has great impact on the flavor and taste of alcoholic beverages, including sake, a traditional Japanese alcoholic beverage. With the growing worldwide interest in… read more here.

Keywords: acid synthase; sake; regulatory subunit; valine ... See more keywords