A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12620
Abstract: Fatty acid synthase (Fasn) is a key component of energy metabolism that is dynamically induced by food intake. Although extensive studies have revealed a number of transcription factors involved in the fasting/refeeding transition of Fasn… read more here.
Keywords: acid synthase; fatty acid; nuclear factor; refeeding response ... See more keywords
Delta-aminolevulinic acid synthase 2 expression in combination with iron as modifiers of disease severity in erythropoietic protoporphyria.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular genetics and metabolism"
DOI: 10.1016/j.ymgme.2019.04.013
Abstract: Deficiency in ferrochelatase (FECH), the last enzyme in the heme biosynthetic pathway, leads to an accumulation of protoporphyrin IX (PPIX) that causes a severely painful phototoxic reaction of the skin in patients with erythropoietic protoporphyria… read more here.
Keywords: erythropoietic protoporphyria; aminolevulinic acid; acid synthase; epp patients ... See more keywords
NeuNAc oxime: A slow-binding and effectively irreversible inhibitor of the sialic acid synthase NeuB.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00654
Abstract: NeuB is a bacterial sialic acid synthase used by neuroinvasive bacteria to synthesize N-acetylneuraminate (NeuNAc), helping them to evade the host immune system. NeuNAc oxime is a potent slow-binding NeuB inhibitor. It dissociated too slowly… read more here.
Keywords: inhibitor; binding; acid synthase; effectively irreversible ... See more keywords
Structure-Based Discovery of Lipoteichoic Acid Synthase Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.2c00300
Abstract: Lipoteichoic acid synthase (LtaS) is a key enzyme for the cell wall biosynthesis of Gram-positive bacteria. Gram-positive bacteria that lack lipoteichoic acid (LTA) exhibit impaired cell division and growth defects. Thus, LtaS appears to be… read more here.
Keywords: structure; acid synthase; compound 1771; lipoteichoic acid ... See more keywords
High-Speed Atomic Force Microscopy Visualization of the Dynamics of the Multienzyme Fatty Acid Synthase.
Sign Up to like & getrecommendations! Published in 2017 at "ACS nano"
DOI: 10.1021/acsnano.7b04216
Abstract: Multienzymes, such as the protein metazoan fatty acid synthase (FAS), are giant and highly dynamic molecular machines for critical biosynthetic processes. The molecular architecture of FAS was elucidated by static high-resolution crystallographic analysis, while electron… read more here.
Keywords: speed atomic; microscopy; fatty acid; acid synthase ... See more keywords
In silico drug repurposing for filarial infection predicts nilotinib and paritaprevir as potential inhibitors of the Wolbachia 5′-aminolevulinic acid synthase
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-87976-4
Abstract: Filarial infections affect millions of individuals and are responsible for some notorious disabilities. Current treatment options involve repeated mass drug administrations, which have been met with several challenges despite some successes. Administration of doxycycline, an… read more here.
Keywords: silico drug; drug repurposing; aminolevulinic acid; drug ... See more keywords
Acetyl-CoA-mediated autoacetylation of fatty acid synthase as a metabolic switch of de novo lipogenesis in Drosophila
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2212220119
Abstract: Significance Metabolic homeostasis plays a vital role in animal growth. Here, we show that acetylation of fatty acid synthase (FASN) contributes to de novolipogenesis during fly development. Although acetylation of most proteins is catalyzed by… read more here.
Keywords: acetyl coa; acid synthase; coa mediated; coa ... See more keywords
Improvement of valine and isobutanol production in sake yeast by Ala31Thr substitution in the regulatory subunit of acetohydroxy acid synthase.
Sign Up to like & getrecommendations! Published in 2023 at "FEMS yeast research"
DOI: 10.1093/femsyr/foad012
Abstract: The fruit-like aroma of two valine-derived volatiles, isobutanol and isobutyl acetate, has great impact on the flavor and taste of alcoholic beverages, including sake, a traditional Japanese alcoholic beverage. With the growing worldwide interest in… read more here.
Keywords: acid synthase; sake; regulatory subunit; valine ... See more keywords
Specialized metabolism by trichome-enriched Rubisco and fatty acid synthase components
Sign Up to like & getrecommendations! Published in 2022 at "Plant Physiology"
DOI: 10.1093/plphys/kiac487
Abstract: Abstract Acylsugars, specialized metabolites with defense activities, are secreted by trichomes of many solanaceous plants. Several acylsugar metabolic genes (AMGs) remain unknown. We previously reported multiple candidate AMGs. Here, using multiple approaches, we characterized additional… read more here.
Keywords: specialized metabolism; acid synthase; trichome; fatty acid ... See more keywords
Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000279
Abstract: BACKGROUND AND AIMS NAFLD has become a major metabolic disease worldwide. A few studies have reported the potential relationship between mitochondrial pyruvate carrier (MPC1) and inflammation, fibrosis, and insulin sensitivity in obese or NASH mouse… read more here.
Keywords: acid synthase; pyruvate carrier; lactylation; mitochondrial pyruvate ... See more keywords
Identification of a fatty acid synthase gene (FAS1) from Laodelphax striatellus planthoppers contributing to fecundity.
Sign Up to like & getrecommendations! Published in 2022 at "Insect science"
DOI: 10.1111/1744-7917.13125
Abstract: Fatty acid synthase (FAS) is a multifunctional enzyme that plays an important role in the formation of fatty acids. The fatty acids take part in many processes such as cell signaling and energy metabolism, and… read more here.
Keywords: acid synthase; insects; gene; fatty acid ... See more keywords