Dynamic Covalent Template-Guided Screen for Nucleic Acid-Targeting Agents.
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DOI: 10.1021/acs.jmedchem.2c01086
Abstract: Trinucleotide repeat diseases such as myotonic dystrophy type 1 (DM1) and Huntington's disease (HD) are caused by expanded DNA repeats that can be used as templates to synthesize their own inhibitors. Because it would be… read more here.
Keywords: nucleic acid; dynamic covalent; chemistry; acid targeting ... See more keywords