Resculpting the binding pocket of APC superfamily LeuT-fold amino acid transporters
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2677-8
Abstract: Amino acid transporters are essential components of prokaryote and eukaryote cells, possess distinct physiological functions, and differ markedly in substrate specificity. Amino acid transporters can be both drug targets and drug transporters (bioavailability, targeting) with… read more here.
Keywords: leut fold; acid transporters; apc superfamily; amino acid ... See more keywords
Amino acid transporters: Emerging roles in drug delivery for tumor-targeting therapy
Sign Up to like & getrecommendations! Published in 2020 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2019.12.002
Abstract: Amino acid transporters, which play a vital role in transporting amino acids for the biosynthesis of mammalian cells, are highly expressed in types of tumors. Increasing studies have shown the feasibility of amino acid transporters… read more here.
Keywords: targeting therapy; acid transporters; tumor targeting; amino acid ... See more keywords
SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109190
Abstract: SUMMARY Pathological lipid accumulation is often associated with enhanced uptake of free fatty acids via specific transporters in cardiomyocytes. Here, we identify SIRT6 as a critical transcriptional regulator of fatty acid transporters in cardiomyocytes. We… read more here.
Keywords: acid transporters; lipid accumulation; fatty acid; transporters cardiomyocytes ... See more keywords
Structure modeling of γ-aminobutyric acid transporters - Molecular basics of ligand selectivity.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.04.263
Abstract: γ-Aminobutyric acid transporters are responsible for regulating the GABA level in the synaptic cleft. In this way, they affect GABA-ergic transmission which is important for the proper functioning of the central nervous system. The exact… read more here.
Keywords: acid transporters; amino acids; structure; selectivity ... See more keywords
Alterations in mRNA expression of glutamate receptor subunits and excitatory amino acid transporters following pilocarpine-induced seizures in rats
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.08.047
Abstract: Temporal lobe epilepsy is the most prevalent form of complex partial seizure, and it is frequently triggered by an initial brain-damaging insult. The prevention of epileptogenesis after a primary event could be a key innovative… read more here.
Keywords: acid transporters; amino acid; receptor subunits; excitatory amino ... See more keywords
Amino acid transporters revisited: New views in health and disease.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2018.05.003
Abstract: Amino acid transporters (AATs) are membrane-bound transport proteins that mediate transfer of amino acids into and out of cells or cellular organelles. AATs have diverse functional roles ranging from neurotransmission to acid-base balance, intracellular energy… read more here.
Keywords: acid transporters; amino; amino acid; transporters revisited ... See more keywords
Technetium-99m complexes of l-arginine derivatives for targeting amino acid transporters.
Sign Up to like & getrecommendations! Published in 2017 at "Dalton transactions"
DOI: 10.1039/c7dt01146f
Abstract: Although relevant from the clinical point of view, radiotracers targeting cationic amino acid transporters are relatively unexplored and, in particular, no metal-based radiotracers are known. The rare examples of complexes recognized by amino acid transporters,… read more here.
Keywords: acid transporters; amino; amino acid; cationic amino ... See more keywords
Effects of spermine on liver barrier function, amino acid transporters, immune status, and apoptosis in piglets
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c8ra05421e
Abstract: This study investigated the effects of spermine supplementation and its extended duration on amino acid transporters, immune status, barrier function, and apoptosis in the liver. read more here.
Keywords: transporters immune; immune status; barrier function; acid transporters ... See more keywords
The effects of maternal nutrition during the first 50 days of gestation on the location and abundance of hexose and cationic amino acid transporters in beef heifer utero-placental tissues.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of animal science"
DOI: 10.1093/jas/skaa386
Abstract: We hypothesized that maternal nutrition during the first 50 d of gestation would influence the abundance of hexose transporters, SLC2A1, SLC2A3, and SLC2A5, and cationic amino acid transporters, SLC7A1 and SLC7A2, in heifer utero-placental tissues.… read more here.
Keywords: gestation; acid transporters; amino acid; placental tissues ... See more keywords
The systems biology of uric acid transporters: the role of remote sensing and signaling
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Nephrology and Hypertension"
DOI: 10.1097/mnh.0000000000000427
Abstract: Purpose of review Uric acid homeostasis in the body is mediated by a number of SLC and ABC transporters in the kidney and intestine, including several multispecific ‘drug’ transporters (e.g., OAT1, OAT3, and ABCG2). Optimization… read more here.
Keywords: uric acid; acid transporters; remote sensing; biology ... See more keywords
Multiple evolutionary origins reflect the importance of sialic acid transporters in the colonization potential of bacterial pathogens and commensals
Sign Up to like & getrecommendations! Published in 2021 at "Microbial Genomics"
DOI: 10.1099/mgen.0.000614
Abstract: Located at the tip of cell surface glycoconjugates, sialic acids are at the forefront of host–microbe interactions and, being easily liberated by sialidase enzymes, are used as metabolites by numerous bacteria, particularly by pathogens and… read more here.
Keywords: acid transporters; pathogens commensals; evolutionary origins; acid ... See more keywords