Critical amino acid variants in HLA-DRB1 allotypes in the development of Graves' disease and Hashimoto's thyroiditis in the Japanese population.
Sign Up to like & getrecommendations! Published in 2020 at "Human immunology"
DOI: 10.1016/j.humimm.2020.12.007
Abstract: The effects of amino acid variants encoded by human leukocyte antigen (HLA) class II on the development of Graves' disease (GD) and Hashimoto's thyroiditis (HT) have not been fully elucidated. We investigated the HLA-DRB1 genes… read more here.
Keywords: acid variants; development; amino acid; hla drb1 ... See more keywords
Pathogenicity Prediction of Single Amino Acid Variants with Machine Learning Model Based on Protein Structural Energies.
Sign Up to like & getrecommendations! Published in 2021 at "IEEE/ACM transactions on computational biology and bioinformatics"
DOI: 10.1109/tcbb.2021.3139048
Abstract: The most popular tools for predicting pathogenicity of single amino acid variants (SAVs) were developed based on sequence-based techniques. SAVs may change protein structure and function. In the context of van der Waals force and… read more here.
Keywords: pathogenicity; acid variants; single amino; prediction ... See more keywords
Single-amino acid variants reveal evolutionary processes that shape the biogeography of a global SAR11 subclade
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.46497
Abstract: Members of the SAR11 order Pelagibacterales dominate the surface oceans. Their extensive diversity challenges emerging operational boundaries defined for microbial 'species' and complicates efforts of population genetics to study their evolution. Here, we employed single-amino… read more here.
Keywords: acid variants; amino acid; single amino; variants reveal ... See more keywords