Copper(I)-catalyzed asymmetric decarboxylative Mannich reaction enabled by acidic activation of 2H-azirines
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DOI: 10.1038/s41467-019-09750-5
Abstract: Chiral aziridines are structure units found in many biologically active compounds and are important building blocks in organic synthesis. Herein, by merging nucleophilic generation through copper(I)-catalyzed decarboxylation and activation of poorly electrophilic 2H-azirines through protonation… read more here.
Keywords: mannich reaction; acidic activation; decarboxylative mannich; activation ... See more keywords