Discovery and Optimization of a Novel Macrocyclic Amidinourea Series Active as Acidic Mammalian Chitinase Inhibitors.
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DOI: 10.1021/acsmedchemlett.2c00472
Abstract: Our research group has been involved for a long time in the development of macrocyclic amidinoureas (MCAs) as antifungal agents. The mechanistic investigation drove us to perform an in silico target fishing study, which allowed… read more here.
Keywords: optimization novel; chitinase; mammalian chitinase; discovery optimization ... See more keywords
Protease resistance of porcine acidic mammalian chitinase under gastrointestinal conditions implies that chitin-containing organisms can be sustainable dietary resources
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DOI: 10.1038/s41598-017-13526-6
Abstract: Chitin, a polymer of N-acetyl-D-glucosamine (GlcNAc), is a major structural component in chitin-containing organism including crustaceans, insects and fungi. Mammals express two chitinases, chitotriosidase (Chit1) and acidic mammalian chitinase (AMCase). Here, we report that pig… read more here.
Keywords: mammalian chitinase; acidic mammalian; gastrointestinal conditions; containing organisms ... See more keywords