Inhibition of host Ogr1 enhances effector CD8+ T-cell function by modulating acidic microenvironment.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer gene therapy"
DOI: 10.1038/s41417-021-00354-0
Abstract: Immunotherapies for cancer, such as immune checkpoint blockade or adoptive T-cell transfer, can lead to a long-lasting clinical response. But the therapeutic response rate remains low on account of many tumors that have evolved sophisticated… read more here.
Keywords: cd8; ogr1; acidic microenvironment; function ... See more keywords
Acidic microenvironment enhances MT1-MMP-mediated cancer cell motility through integrinβ1/cofilin/F-actin axis.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biochimica et biophysica Sinica"
DOI: 10.1093/abbs/gmab130
Abstract: Tumor acidic microenvironment is the main feature of many solid tumors. As a part of the tumor microenvironment, it has a profound impact on the occurrence and development of tumors. However, the research on how… read more here.
Keywords: cell motility; microenvironment; cancer; acidic microenvironment ... See more keywords
Weakly acidic microenvironment of the wound bed boosting the efficacy of acidic fibroblast growth factor to promote skin regeneration
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1150819
Abstract: The pH value within the wound microenvironment influences indirectly and directly all biochemical reactions taking place in the process of skin wound healing. Currently, it is generally believed that a low pH value, such as… read more here.
Keywords: wound; microenvironment wound; skin; microenvironment ... See more keywords
Acidic microenvironment triggered in situ assembly of activatable three-arm aptamer nanoclaw for contrast-enhanced imaging and tumor growth inhibition in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.72028
Abstract: Rationale: Static assembled multivalent DNA nanotheranostics system have encountered some bottleneck problems in cancer imaging and therapy, such as poor penetration and high immunogenicity. Herein, we proposed an acidic tumor microenvironment triggered assembly of activatable… read more here.
Keywords: microenvironment triggered; acidic microenvironment; tumor; contrast enhanced ... See more keywords