Use of acidic nanoparticles to rescue macrophage lysosomal dysfunction in atherosclerosis
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DOI: 10.1080/15548627.2022.2108252
Abstract: ABSTRACT Dysfunction in the macrophage lysosomal system including reduced acidity and diminished degradative capacity is a hallmark of atherosclerosis, leading to blunted clearance of excess cellular debris and lipids in plaques and contributing to lesion… read more here.
Keywords: acidic nanoparticles; rescue macrophage; lysosomal dysfunction; macrophage ... See more keywords
Acidic nanoparticles protect against α‐synuclein‐induced neurodegeneration through the restoration of lysosomal function
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13584
Abstract: Parkinson's disease (PD) is an age‐related neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, associated with the accumulation of misfolded α‐synuclein and lysosomal impairment, two events deemed interconnected. Protein aggregation… read more here.
Keywords: acidic nanoparticles; nanoparticles protect; lysosomal function; synuclein ... See more keywords