T-cells produce acidic niches in lymph nodes to suppress their own effector functions
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DOI: 10.1038/s41467-020-17756-7
Abstract: The acidic pH of tumors profoundly inhibits effector functions of activated CD8 + T-cells. We hypothesize that this is a physiological process in immune regulation, and that it occurs within lymph nodes (LNs), which are likely acidic… read more here.
Keywords: lymph nodes; effector functions; acidic niches; activation ... See more keywords