Acidic patch histone mutations and their effects on nucleosome remodeling.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society transactions"
DOI: 10.1042/bst20210773
Abstract: Structural and biochemical studies have identified a histone surface on each side of the nucleosome disk termed 'the nucleosome acidic patch' that acts as a regulatory hub for the function of numerous nuclear proteins, including… read more here.
Keywords: nucleosome remodeling; patch histone; histone mutations; acidic patch ... See more keywords
Multivalent DNA and nucleosome acidic patch interactions specify VRK1 mitotic localization and activity
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DOI: 10.1093/nar/gkac198
Abstract: Abstract A key role of chromatin kinases is to phosphorylate histone tails during mitosis to spatiotemporally regulate cell division. Vaccinia-related kinase 1 (VRK1) is a serine–threonine kinase that phosphorylates histone H3 threonine 3 (H3T3) along… read more here.
Keywords: multivalent dna; patch interactions; nucleosome acidic; dna nucleosome ... See more keywords
Dual engagement of the nucleosomal acidic patches is essential for deposition of histone H2A.Z by SWR1C
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DOI: 10.7554/elife.94869
Abstract: The yeast SWR1C chromatin remodeling enzyme catalyzes the ATP-dependent exchange of nucleosomal histone H2A for the histone variant H2A.Z, a key variant involved in a multitude of nuclear functions. How the 14-subunit SWR1C engages the… read more here.
Keywords: nucleosomal acidic; deposition; acidic patch; histone h2a ... See more keywords