Role of the activation peptide in the mechanism of protein C activation
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DOI: 10.1038/s41598-020-68078-z
Abstract: Protein C is a natural anticoagulant activated by thrombin in a reaction accelerated by the cofactor thrombomodulin. The zymogen to protease conversion of protein C involves removal of a short activation peptide that, relative to… read more here.
Keywords: protein; role activation; acidic residues; activation ... See more keywords
Binding of the periplakin linker requires vimentin acidic residues D176 and E187
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DOI: 10.1038/s42003-020-0810-y
Abstract: Plakin proteins form connections that link the cell membrane to the intermediate filament cytoskeleton. Their interactions are mediated by a highly conserved linker domain through an unresolved mechanism. Here analysis of the human periplakin linker… read more here.
Keywords: periplakin linker; acidic residues; binding; linker ... See more keywords