Improved therapeutic index of an acidic pH-selective antibody
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DOI: 10.1080/19420862.2021.2024642
Abstract: ABSTRACT Although therapeutically efficacious, ipilimumab can exhibit dose-limiting toxicity that prevents maximal efficacious clinical outcomes and can lead to discontinuation of treatment. We hypothesized that an acidic pH-selective ipilimumab (pH Ipi), which preferentially and reversibly… read more here.
Keywords: selective antibody; therapeutic index; improved therapeutic; acidic selective ... See more keywords