Preferential precipitation of acidic variants from monoclonal antibody pools
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DOI: 10.1002/bit.28257
Abstract: Microheterogeneity of monoclonal antibodies (mAbs) can impact their activity and stability. Formation of charge variants is considered as the most important source of the microheterogeneity. In particular, controlling the content of the acidic species is… read more here.
Keywords: precipitation acidic; preferential precipitation; acidic variants; variants monoclonal ... See more keywords
Challenges and Strategies for a Thorough Characterization of Antibody Acidic Charge Variants
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DOI: 10.3390/bioengineering9110641
Abstract: Heterogeneity of therapeutic Monoclonal antibody (mAb) drugs are due to protein variants generated during the manufacturing process. These protein variants can be critical quality attributes (CQAs) depending on their potential impact on drug safety and/or… read more here.
Keywords: charge variants; characterization; thorough characterization; acidic variants ... See more keywords