Association of Metformin Use With Risk of Lactic Acidosis Across the Range of Kidney Function: A Community-Based Cohort Study
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Internal Medicine"
DOI: 10.1001/jamainternmed.2018.0292
Abstract: Importance Approximately 1 million patients in the United States with type 2 diabetes mellitus and mild-to-moderate kidney disease do not receive guideline-directed therapy with metformin. This may reflect uncertainty regarding the risk of acidosis in… read more here.
Keywords: acidosis; use; egfr min; metformin ... See more keywords
Extracellular acidosis stimulates breast cancer cell motility through aryl hydrocarbon receptor and c‐src kinase activation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30275
Abstract: A reduction in extracellular pH (pHe) is a characteristic of most malignant tumors. The aryl hydrocarbon receptor (AhR) is a transcription factor localized in a cytosolic complex with c‐Src, which allows it to trigger nongenomic… read more here.
Keywords: breast cancer; cell; ahr src; acidosis ... See more keywords
A severe linezolid‐induced rhabdomyolysis and lactic acidosis in Leigh syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12328
Abstract: To the Editor, Recently, De Vries et al. reported the results of a Delphi-based workshop to develop consensus guidelines for physicians prescribing drugs for patients with mitochondrial diseases. The pharmacological management of these subjects is… read more here.
Keywords: acidosis; leigh syndrome; lactic acidosis; rhabdomyolysis ... See more keywords
The subfornical organ regulates acidosis‐evoked fear by engaging microglial acid‐sensor TDAG8 and forebrain neurocircuits in male mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25059
Abstract: An important role of pH homeostasis has been suggested in the physiology of panic disorder, with acidosis as an interoceptive trigger leading to fear and panic. Identification of novel mechanisms that can translate acidosis into… read more here.
Keywords: acidosis; acid; physiology; fear ... See more keywords
What about permissive acidosis?
Sign Up to like & getrecommendations! Published in 2022 at "Intensive Care Medicine"
DOI: 10.1007/s00134-022-06696-z
Abstract: We read with great interest the systematic review and meta-analysis by Gendreau and colleagues [1] examining the relation between hypercapnia and mortality in patients affected by acute respiratory distress syndrome (ARDS). We would like, however,… read more here.
Keywords: acidosis; care; ventilation; permissive acidosis ... See more keywords
Prevalence and risk factors of lactic acidosis in children with acute moderate and severe asthma, a prospective observational study
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Pediatrics"
DOI: 10.1007/s00431-020-03834-x
Abstract: Lactic acidosis is a common complication of status asthmaticus in adults. However, data is sparse in children. The aim of this study was to describe the prevalence and risk factors for lactic acidosis in children… read more here.
Keywords: acidosis; factors lactic; lactic acidosis; risk factors ... See more keywords
Causes, consequences, and therapy of tumors acidosis
Sign Up to like & getrecommendations! Published in 2019 at "Cancer and Metastasis Reviews"
DOI: 10.1007/s10555-019-09792-7
Abstract: While cancer is commonly described as “a disease of the genes,” it is also associated with massive metabolic reprogramming that is now accepted as a disease “Hallmark.” This programming is complex and often involves metabolic… read more here.
Keywords: acidosis; tumors acidosis; therapy tumors; consequences therapy ... See more keywords
Acute Ethanol Exposure Promotes Autophagy-Lysosome Pathway-Dependent ASIC1a Protein Degradation and Protects Against Acidosis-Induced Neurotoxicity
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1289-0
Abstract: Tissue acidosis is a common feature of brain ischemia which causes neuronal injury. Activation of acid-sensing ion channel 1a (ASIC1a) plays an important role in acidosis-mediated neurotoxicity. Acute ethanol administration has been shown to provide… read more here.
Keywords: acidosis; asic1a; induced neurotoxicity; acidosis induced ... See more keywords
Prevalence of Metabolic Acidosis Among Patients with Chronic Kidney Disease and Hyperkalemia
Sign Up to like & getrecommendations! Published in 2021 at "Advances in Therapy"
DOI: 10.1007/s12325-021-01886-5
Abstract: Although hyperkalemia and metabolic acidosis often co-occur in patients with chronic kidney disease (CKD), the prevalence of metabolic acidosis among patients with CKD and hyperkalemia is understudied. Therefore, we used medical record data from the… read more here.
Keywords: acidosis; prevalence metabolic; among patients; hyperkalemia ... See more keywords
The Association between Metformin Therapy and Lactic Acidosis
Sign Up to like & getrecommendations! Published in 2019 at "Drug Safety"
DOI: 10.1007/s40264-019-00854-x
Abstract: There is increasing evidence to suggest that therapeutic doses of metformin are unlikely to cause lactic acidosis. The aims of this research were (1) to formally evaluate the association between metformin therapy and lactic acidosis… read more here.
Keywords: acidosis; metformin associated; lactic acidosis; association ... See more keywords
Nasal flaring as a clinical sign of respiratory acidosis in patients with dyspnea
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Emergency Medicine"
DOI: 10.1016/j.ajem.2016.12.008
Abstract: Objective: To determine whether the presence of nasal flaring is a clinical sign of respiratory acidosis in patients attending emergency departments for acute dyspnea. Methods: Single‐center, prospective, observational study of patients aged over 15 requiring… read more here.
Keywords: acidosis; flaring clinical; presence; clinical sign ... See more keywords