Acidotoxicity via ASIC1a Mediates Cell Death during Oxygen Glucose Deprivation and Abolishes Excitotoxicity.
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DOI: 10.1021/acschemneuro.6b00355
Abstract: Ischemic reperfusion (I/R) injury is associated with a complex and multifactorial cascade of events involving excitotoxicity, acidotoxicity, and ionic imbalance. While it is known that acidosis occurs concomitantly with glutamate-mediated excitotoxicity during brain ischemia, it… read more here.
Keywords: excitotoxicity; glucose deprivation; acidotoxicity; oxygen glucose ... See more keywords