Synthesis of new quinazoline-containing hydroxamic acids as potential HDAC/VEGFR inhibitors. Unusual rearrangements with pyrrolidone ring opening and dehydration of 3-N-hydroxyquinazoline fragment containing tetracycles
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.151315
Abstract: Abstract Synthesis pathways were developed and new hydroxamic acids were obtained as potential inhibitors of HDAC/VEGFR2, including tetracycles containing quinazolinone fragment as a “cap”. Further biological testing of the obtained compounds will give an opportunity… read more here.
Keywords: containing hydroxamic; synthesis new; new quinazoline; hydroxamic acids ... See more keywords
Synthesis of Naphthoic Acids as Potential Anticancer Agents
Sign Up to like & getrecommendations! Published in 2018 at "Synlett"
DOI: 10.1055/s-0037-1611342
Abstract: As part of ongoing research to investigate structural requirements for lactate dehydrogenase inhibition by highly substituted naphthoic acids, nine new aryl-substituted dihydroxynaphthoic acids were synthesized from three known precursors. Described here are efficient preparations of… read more here.
Keywords: anticancer agents; acids potential; synthesis naphthoic; naphthoic acids ... See more keywords
Polyunsaturated Fatty Acids and Their Potential Therapeutic Role in Cardiovascular System Disorders—A Review
Sign Up to like & getrecommendations! Published in 2018 at "Nutrients"
DOI: 10.3390/nu10101561
Abstract: Cardiovascular diseases are described as the leading cause of morbidity and mortality in modern societies. Therefore, the importance of cardiovascular diseases prevention is widely reflected in the increasing number of reports on the topic among… read more here.
Keywords: polyunsaturated fatty; fatty acids; acids potential; cardiovascular diseases ... See more keywords
Flavonoids and Phenolic Acids as Potential Natural Antioxidants
Sign Up to like & getrecommendations! Published in 2019 at "Antioxidants"
DOI: 10.5772/intechopen.83731
Abstract: For centuries, aromatic herbs and spices have been added to different foods to improve the flavor and organoleptic properties. The use of aromatic plants and spices in phytotherapy is mostly related to different activities of… read more here.
Keywords: potential natural; phenolic acids; flavonoids phenolic; natural antioxidants ... See more keywords