Synthesis of Bisboronic Acids and Their Selective Recognition of Sialyl Lewis X Antigen
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Research in Chinese Universities"
DOI: 10.1007/s40242-018-7328-6
Abstract: The development of sensors that recognize Lewis oligosaccharides can help the diagnosis and early detection of cancer. Herein, we reported the design and synthesis of a series of anthracene-based bisboronic acids (9a—9e) with different N-substituents… read more here.
Keywords: acids selective; synthesis bisboronic; sialyl lewis; selective recognition ... See more keywords
Indazole-6-phenylcyclopropylcarboxylic Acids as Selective GPR120 Agonists with in Vivo Efficacy.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b00210
Abstract: GPR120 agonists have therapeutic potential for the treatment of diabetes, but few selective agonists have been reported. We identified an indazole-6-phenylcyclopropylcarboxylic acid series of GPR120 agonists and conducted SAR studies to optimize GPR120 potency. Furthermore,… read more here.
Keywords: acids selective; indazole phenylcyclopropylcarboxylic; selective gpr120; gpr120 agonists ... See more keywords