Synthesis of α‐Fluoroketones from Carboxylic Acids via Decarboxylation of Fluorinated Malonates
Sign Up to like & getrecommendations! Published in 2025 at "Helvetica Chimica Acta"
DOI: 10.1002/hlca.202400187
Abstract: α‐Fluoroketones are versatile intermediates in the synthesis of fluorinated heterocycles and other fluorine‐containing building blocks. We have recently disclosed a novel route to such an α‐fluoroketone using the corresponding benzoic acid as a starting material.… read more here.
Keywords: decarboxylation; acids via; via decarboxylation; synthesis fluoroketones ... See more keywords
Recent advancement in deoxygenation of fatty acids via homogeneous catalysis for biofuel production
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Catalysis"
DOI: 10.1016/j.mcat.2020.111207
Abstract: Abstract Fuel-like hydrocarbons (also known as biofuel) isolated from the deoxygenation of fatty acids present different advantages as compared with fossil fuels. In particular, the homogeneous and heterogeneous catalytic deoxygenation methods have been the center… read more here.
Keywords: acids via; deoxygenation fatty; biofuel; catalysis ... See more keywords
Ligand-Enabled C-H Olefination and Lactonization of Benzoic Acids and Phenylacetic Acids via Palladium Catalyst.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.1c04000
Abstract: A novel ligand propan-2-one O-(p-tolylcarbamoyl) oxime (L7) has been developed to promote C(sp2)-H olefination of benzoic acids and phenylacetic acids via a palladium catalyst. With the subsequent lactonization of the olefinated products through 1,4-addition, highly… read more here.
Keywords: phenylacetic acids; acids phenylacetic; palladium catalyst; acids via ... See more keywords
Nickel(0)-Catalyzed Decarbonylative Cross-Coupling of Aromatic Esters with Arylboronic Acids via Chelation Assistance
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c01105
Abstract: 10-Arylbenzo[h]quinolines were synthesized by cross-coupling of ethyl benzo[h]quinoline-10-carboxylate with arylboronic acids via group-directed Ni(0) catalyzation. The catalytic system combining Ni(COD)2 (10 mol %) with PCy3 (20 mol %) and t-BuOK (3 equiv) was optimal for… read more here.
Keywords: cross coupling; nickel catalyzed; catalyzed decarbonylative; acids via ... See more keywords
Catalyst- and Additive-Free C(sp3)–H Functionalization of (Thio)barbituric Acids via C-5 Dehydrogenative Aza-Coupling Under Ambient Conditions
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c03073
Abstract: A one-pot room-temperature-based three-component reaction strategy has been accomplished to access a new series of bio-relevant barbituric/2-thiobarbituric acid hydrazones from the reaction between barbituric/2-thiobarbituric acids, primary aromatic amines, and tert-butyl nitrite in an acetonitrile solvent,… read more here.
Keywords: via dehydrogenative; sp3 functionalization; reaction; acids via ... See more keywords
Aerobic oxidative α-arylation of furans with boronic acids via Pd(ii)-catalyzed C-C bond cleavage of primary furfuryl alcohols: sustainable access to arylfurans.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc07111f
Abstract: Aerobic oxidative α-arylation of furans with boronic acids via Pd(ii)-catalyzed C-C bond cleavage of primary furfuryl alcohols provides sustainable access to arylfurans. This protocol opens a new avenue for the transformation of readily available furans… read more here.
Keywords: boronic acids; oxidative arylation; furans boronic; arylation furans ... See more keywords
Functionalization of arylacetic acids via directing-group-assisted remote meta-C-H activation.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc01050c
Abstract: Herein, we report the first microwave-assisted remote-C-H functionalization aided by a simple nitrile directing template. Notably, the present protocol showed a broad substrate scope VIA enabling meta-C-H arylation, acetoxylation, and cyanation. Significantly, the microwave-accelerated meta-C-H… read more here.
Keywords: assisted remote; functionalization; acids via; via directing ... See more keywords
Modular synthesis of congested β2,2-amino acids via the merger of photocatalysis and oxidative functionalisations.
Sign Up to like & getrecommendations! Published in 2024 at "Chemical communications"
DOI: 10.1039/d3cc06172h
Abstract: A two-step protocol for the modular synthesis of β2- and α-quaternary β2,2-amino acid derivatives is reported. The key steps are a photocatalytic hydroalkylation reaction, followed by an oxidative functionalisation to access N-protected β-amino acids, esters,… read more here.
Keywords: synthesis congested; congested amino; acids via; amino acids ... See more keywords
Direct access to hydrazides and amides from carboxylic acids via acyloxyphosphonium ion
Sign Up to like & getrecommendations! Published in 2024 at "Organic Chemistry Frontiers"
DOI: 10.1039/d3qo02062b
Abstract: Adding an amine moiety to a carbonyl group poses a challenging synthetic task; nevertheless, it is a crucial step in developing numerous bioactive molecules. read more here.
Keywords: direct access; acids via; access hydrazides; hydrazides amides ... See more keywords
Enantioseparation of 3-Hydroxycarboxylic Acids via Diastereomeric Salt Formation by 2-Amino-1,2-diphenylethanol (ADPE) and Cinchonidine
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules28010114
Abstract: Enantioseparation of 3-hydroxycarboxylic acids via diastereomeric salt formation was demonstrated using 2-amino-1,2-diphenylethanol (ADPE) and cinchonidine as the resolving agents. Racemic 3-hydroxy-4-phenylbutanoic acid (rac-1), 3-hydroxy-4-(4-chlorophenyl)butanoic acid (rac-2), and 3-hydroxy-5-phenylpentanoic acid (rac-3) were efficiently resolved using these… read more here.
Keywords: diastereomeric salt; cinchonidine; acids via; hydroxycarboxylic acids ... See more keywords