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   Articles with "acinar" as a keyword



Salivary gland cell aggregates are derived from self-organization of acinar lineage cells.

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recommendations! Published in 2019 at "Archives of oral biology"

DOI: 10.1016/j.archoralbio.2018.10.017

Abstract: OBJECTIVE The objective of this study was to characterize the mechanism by which salivary gland cells (SGC) aggregate in vitro. DESIGN Timelapse microscopy was utilized to analyze the process of salivary gland aggregate formation using… read more here.

Keywords: acinar; gland cell; salivary gland; gland ... See more keywords

Integrative Genomic Analysis of Coincident Cancer Foci Implicates CTNNB1 and PTEN Alterations in Ductal Prostate Cancer.

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recommendations! Published in 2017 at "European urology focus"

DOI: 10.1016/j.euf.2017.12.003

Abstract: BACKGROUND Ductal adenocarcinoma of the prostate is an aggressive subtype, with high rates of biochemical recurrence and overall poor prognosis. It is frequently found coincident with conventional acinar adenocarcinoma. The genomic features driving evolution to… read more here.

Keywords: acinar; prostate cancer; cancer; adenocarcinoma ... See more keywords
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Adult Pancreatic Acinar Progenitor-like Populations in Regeneration and Cancer.

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recommendations! Published in 2020 at "Trends in molecular medicine"

DOI: 10.1016/j.molmed.2020.04.003

Abstract: The bulk of the pancreas primarily comprises long-lived acinar cells that are not considered a bona fide source for stem cells. However, certain acinar subpopulations have a repopulating capacity during regeneration, raising the hypothesis as… read more here.

Keywords: acinar; regeneration; like populations; cancer ... See more keywords

PROSTATIC DUCTAL ADENOCARCINOMA CONTROLLED FOR CANCER GRADE AND TUMOR VOLUME DOES NOT HAVE AN INDEPENDENT EFFECT ON ADVERSE RADICAL PROSTATECTOMY OUTCOMES COMPARED TO USUAL ACINAR PROSTATIC ADENOCARCINOMA.

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recommendations! Published in 2019 at "Urology"

DOI: 10.1016/j.urology.2019.10.014

Abstract: OBJECTIVE To study if prostatic ductal adenocarcinoma (PDA) controlled by Grade Group (GG), PSA, and tumor volume (TV) is an independent predictor of adverse radical prostatectomy (RP) outcomes. MATERIALS One-hundred-and-twenty-eight PDA and 1,141 acinar continuous… read more here.

Keywords: acinar; pda; prostatic ductal; effect ... See more keywords

Enhanced proliferation of pancreatic acinar cells in MRL/MpJ mice is driven by severe acinar injury but independent of inflammation

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-27422-0

Abstract: Adult pancreatic acinar cells have the ability to re-enter the cell cycle and proliferate upon injury or tissue loss. Despite this mitotic ability, the extent of acinar proliferation is often limited and unable to completely… read more here.

Keywords: acinar; mpj mice; proliferation; mrl mpj ... See more keywords

High concentrations of L-lysine cause mitochondrial damage and necrosis in isolated pancreatic acinar cells.

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recommendations! Published in 2025 at "Scientific reports"

DOI: 10.1038/s41598-025-29890-7

Abstract: Intraperitoneal administration of high doses of basic amino acids, such as L-lysine (L-Lys), L-arginine (L-Arg) or L-ornithine (L-Orn) induces acute pancreatitis in rodents. Although the exact mechanism of their action is not fully understood, the… read more here.

Keywords: necrosis; pancreatic acinar; high concentrations; acinar cells ... See more keywords

A Novel Approach for Pancreas Transcriptomics Reveals the Cellular Landscape in Homeostasis and Acute Pancreatitis.

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recommendations! Published in 2024 at "Gastroenterology"

DOI: 10.1053/j.gastro.2024.01.043

Abstract: BACKGROUND & AIMS Acinar cells produce digestive enzymes that impede transcriptomic characterization of the exocrine pancreas. Thus, single-cell RNA-sequencing (scRNA-seq) studies of the pancreas underrepresent acinar cells relative to histological expectations, and a robust approach… read more here.

Keywords: homeostasis acute; acute pancreatitis; cell; approach ... See more keywords
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Metastatic mixed acinar‐neuroendocrine carcinoma of the pancreas treated by a multidisciplinary team: A case report and brief review of the literature

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recommendations! Published in 2019 at "Journal of Digestive Diseases"

DOI: 10.1111/1751-2980.12752

Abstract: Ranked the fourth or fifth most common cause of cancer globally, pancreatic cancer is recognized as "the king of cancer" for the high malignant potential (1). Pancreatic cancer develops from either the endocrine (islet cell)… read more here.

Keywords: acinar; mixed acinar; metastatic mixed; cancer ... See more keywords

Abstract B055: Hyperinsulinemia acts via acinar cell insulin receptors to drive obesity-associated pancreatic cancer initiation

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recommendations! Published in 2024 at "Cancer Research"

DOI: 10.1158/1538-7445.panca2023-b055

Abstract: The rising incidence of pancreatic cancer is largely driven by increased prevalence of obesity and type 2 diabetes (T2D). Hyperinsulinemia is a cardinal feature of obesity and T2D, and is associated with increased cancer incidence… read more here.

Keywords: cancer; insulin; obesity; pancreatic cancer ... See more keywords

A Case Report of Acinar Cell Cystadenoma with Pancreatic Intraepithelial Neoplasia: Is It Always Benign?

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recommendations! Published in 2025 at "Case Reports in Gastroenterology"

DOI: 10.1159/000546668

Abstract: Abstract Introduction: The exact etiology of acinar cell cystadenoma (ACC) has been debated, primarily whether it originates from or carries the risk of an underlying neoplasia. Pancreatic intraepithelial neoplasia (PanIN) is presumed to be a… read more here.

Keywords: cell cystadenoma; acinar cell; lesion; pancreatic intraepithelial ... See more keywords

Primary Pure Pancreatic -Type Acinar Cell Carcinoma of the Stomach: A Rare Entity with a Difficult Diagnosis and Review of the Literature

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recommendations! Published in 2022 at "International Journal of Surgical Pathology"

DOI: 10.1177/10668969211065763

Abstract: Acinar cell carcinoma is an uncommon tumour, representing only 1% to 2% of all exocrine pancreatic tumours. Pancreatic-type acinar cell carcinoma can occur in other organs, including the stomach, but it is extraordinarily rare. We… read more here.

Keywords: cell carcinoma; cell; pancreatic type; acinar ... See more keywords