Chrm3 protects against acinar cell necrosis by stabilizing caspase‐8 expression in severe acute pancreatitis mice model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29483
Abstract: Acinar cells in acute pancreatitis (AP) die through apoptosis and necrosis, the impacts of which are quite different. Early clinical interference strategies on preventing the progress of AP to severe acute pancreatitis (SAP) are the… read more here.
Keywords: acute pancreatitis; necrosis; pancreatitis; severe acute ... See more keywords
Defining the role of systemic therapy in resectable pancreatic acinar cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.26785
Abstract: Following resection of pancreatic acinar cell carcinoma (PACC) distant recurrence remains high. We utilized the national cancer database (NCDB) to evaluate the role of systemic therapy in early‐stage resected PACC. read more here.
Keywords: cell carcinoma; role systemic; pancreatic acinar; acinar cell ... See more keywords
P53 Activated by ER Stress Aggravates Caerulein-Induced Acute Pancreatitis Progression by Inducing Acinar Cell Apoptosis
Sign Up to like & getrecommendations! Published in 2020 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-020-06052-5
Abstract: Background and Aims Acute pancreatitis (AP) is a severe pancreatic disorder that remains associated with high mortality due to a lack of effective drugs and management strategies. This study aimed to investigate the molecular pathogenic… read more here.
Keywords: cell apoptosis; stress; acinar cell; p53 ... See more keywords
Development of Pancreatic Acinar Cell Metaplasia During Gastric Repair in a Rat Duodenal Contents Reflux Model
Sign Up to like & getrecommendations! Published in 2020 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-020-06342-y
Abstract: Background We previously reported the development of pancreatic acinar cell metaplasia (PACM) in the glandular stomach of a duodenal contents reflux model (reflux model). Aims We aimed to investigate the characteristics and histogenesis of PACM… read more here.
Keywords: pancreatic acinar; contents reflux; model; acinar cell ... See more keywords
The Unusual Suspects of the Pancreas—Understanding Pancreatic Acinar Cell Carcinomas and Adenomas
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Gastrointestinal Cancer"
DOI: 10.1007/s12029-019-00231-y
Abstract: Purpose Acinar cell carcinomas (ACC) and adenomas (ACA) of the pancreas are rare entities. Sufficient knowledge about occurrence and prognosis is scarce. Methods A retrospective chart review of our database was performed for all patients… read more here.
Keywords: unusual suspects; acinar cell; cell carcinomas;
The surgical management of metastatic pancreatic acinar cell carcinoma and associated pancreatic panniculitis—A case report and literature review
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Surgery Case Reports"
DOI: 10.1016/j.ijscr.2020.10.062
Abstract: Highlights • Pancreatic acinar cell carcinoma (ACC) may present with pancreatic panniculitis.• Complete surgical resection of ACC can successfully treat pancreatic panniculitis.• Aggressive surgery for ACC can lead to prolonged disease-free survival. read more here.
Keywords: pancreatic acinar; panniculitis; cell carcinoma; pancreatic panniculitis ... See more keywords
Acinar cell carcinoma of the pancreas presenting as diffuse pancreatic enlargement
Sign Up to like & getrecommendations! Published in 2017 at "Medicine"
DOI: 10.1097/md.0000000000007904
Abstract: Rationale: Pancreatic acinar cell carcinoma (ACC) is a rare malignant tumor of exocrine pancreas. It is typically a well-marginated large solid mass arising in a certain aspect of the pancreas. Diffuse involvement of ACC in… read more here.
Keywords: cell carcinoma; acinar cell; presenting diffuse;
Response of germline BRCA2-mutated advanced pancreatic acinar cell carcinoma to olaparib
Sign Up to like & getrecommendations! Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000013113
Abstract: Rationale: Pancreatic acinar cell carcinoma (PACC) is a relatively rare malignancy of the exocrine pancreas. BRCA2, a cancer susceptibility gene, has been widely studied in breast and ovarian carcinomas as mutation carriers for this gene… read more here.
Keywords: pancreatic acinar; cell carcinoma; germline brca2; acinar cell ... See more keywords
Recent Insights Into the Pathogenic Mechanism of Pancreatitis: Role of Acinar Cell Organelle Disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Pancreas"
DOI: 10.1097/mpa.0000000000001298
Abstract: Acute pancreatitis (AP) is a potentially lethal inflammatory disease that lacks specific therapy. Damaged pancreatic acinar cells are believed to be the site of AP initiation. The primary function of these cells is the synthesis,… read more here.
Keywords: pancreatitis; acinar cell; organelle disorders; cell ... See more keywords
Apigenin Decreases Acinar Cell Damage in Pancreatitis
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DOI: 10.1097/mpa.0000000000001310
Abstract: Objective Chronic pancreatitis is the consequence of multiple episodes of recurrent acute pancreatitis (RAP). We hypothesized that apigenin can minimize the sequelae of RAP by limiting acinar cells' proinflammatory signaling pathways. Methods AR42J acinar cells… read more here.
Keywords: pancreatitis; acinar cell; apigenin; bgr ... See more keywords
Exceptional Response of Pancreatic Acinar Cell Carcinoma and Bile Duct Cancer to Platinum-Based Chemotherapy in a Family With a Germline BRCA2 Variant.
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DOI: 10.1097/mpa.0000000000002150
Abstract: ABSTRACT Pancreatic cancer and its rare subtype, acinar cell carcinoma (PACC), frequently harbor germline and/or somatic variants in homologous recombinant genes, including BRCA2. Individuals possessing germline pathogenic BRCA2 variants are known to have a higher… read more here.
Keywords: germline; brca2; brca2 variant; acinar cell ... See more keywords