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   Articles with "acinar cells" as a keyword



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Perfluorooctanoic acid activates the unfolded protein response in pancreatic acinar cells

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recommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"

DOI: 10.1002/jbt.22561

Abstract: Perfluoroalkyl substances, such as perfluorooctanoic acid (PFOA), are widely used in consumer and industrial applications. Human epidemiologic and animal studies suggest that PFOA exposure elicits adverse effects on the pancreas; however, little is known about… read more here.

Keywords: perfluorooctanoic acid; pancreatic acinar; pfoa; unfolded protein ... See more keywords
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Research Progress on the Relationship Between Acute Pancreatitis and Calcium Overload in Acinar Cells

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recommendations! Published in 2018 at "Digestive Diseases and Sciences"

DOI: 10.1007/s10620-018-5297-8

Abstract: Acute pancreatitis is a human disease with multiple causes that leads to autodigestion of the pancreas. There is sufficient evidence to support the key role of sustained increase in cytosolic calcium concentrations in the early… read more here.

Keywords: acute pancreatitis; overload acinar; calcium overload; acinar cells ... See more keywords

Maintenance of claudin-3 expression and the barrier functions of intercellular junctions in parotid acinar cells via the inhibition of Src signaling.

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recommendations! Published in 2017 at "Archives of oral biology"

DOI: 10.1016/j.archoralbio.2017.05.007

Abstract: OBJECTIVES Salivary acinar and duct cells show different expression patterns of claudins, which may reflect their different functions. To study the role of claudins in saliva secretion, we examined alterations in the expression patterns of… read more here.

Keywords: claudin; parotid acinar; barrier function; expression ... See more keywords
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Recovery of atrophic parotid glands in rats fed a liquid diet by switching to a pellet diet.

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recommendations! Published in 2018 at "Archives of oral biology"

DOI: 10.1016/j.archoralbio.2018.08.015

Abstract: OBJECTIVE In this study, we aimed to clarify how parotid glands, made atrophic by a liquid diet, recover after diet change. DESIGN Seven-week-old male Wistar rats were fed a pellet (control group) or a liquid… read more here.

Keywords: parotid glands; group; liquid diet; acinar cells ... See more keywords
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Undercarboxylated osteocalcin downregulates pancreatic lipase expression in an ATF4-dependent manner in pancreatic acinar cells.

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recommendations! Published in 2019 at "Bone"

DOI: 10.1016/j.bone.2019.06.009

Abstract: Osteocalcin is an osteoblast-specific secreted protein that has been associated with endocrine roles in multiple aspects of energy metabolism. We examined whether undercarboxylated osteocalcin (ucOC) downregulates pancreatic lipase (PNLIP) expression in pancreatic acinar cells and… read more here.

Keywords: pancreatic acinar; pnlip expression; expression; acinar cells ... See more keywords
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Polarity of action in salivary gland acinar cells: Local and preferential Ca2+ signalling.

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recommendations! Published in 2021 at "Cell calcium"

DOI: 10.1016/j.ceca.2021.102471

Abstract: Salivary secretion is important for digestion and paramount for oral health. Both exocytotic secretion of proteins (including salivary amylase and mucins) and fluid secretion contribute to the formation of saliva. A recent study by T.… read more here.

Keywords: acinar cells; secretion; salivary gland; polarity action ... See more keywords
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Rab9 mediates pancreatic autophagy switch from canonical to noncanonical, aggravating experimental pancreatitis.

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recommendations! Published in 2021 at "Cellular and molecular gastroenterology and hepatology"

DOI: 10.1016/j.jcmgh.2021.09.017

Abstract: BACKGROUND Autophagosome, the central organelle in autophagy process, can assemble via canonical pathway mediated by LC3-II, the lipidated form of autophagy-related protein LC3/ATG8, or noncanonical pathway mediated by the small GTPase Rab9. Canonical autophagy is… read more here.

Keywords: pancreatitis; pancreatic autophagy; rab9; autophagy ... See more keywords
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Pancreas: FGF21 gets the juices flowing

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recommendations! Published in 2017 at "Nature Reviews Endocrinology"

DOI: 10.1038/nrendo.2017.7

Abstract: stimulates the secretion of digestive enzymes from acinar cells in the exocrine pancreas and the flow of pancreatic juices, according to a new study published in Cell Metabolism. The researchers, led by David Mangelsdorf and… read more here.

Keywords: digestive enzymes; juice flow; fgf21; stress ... See more keywords
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Enhanced proliferation of pancreatic acinar cells in MRL/MpJ mice is driven by severe acinar injury but independent of inflammation

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-27422-0

Abstract: Adult pancreatic acinar cells have the ability to re-enter the cell cycle and proliferate upon injury or tissue loss. Despite this mitotic ability, the extent of acinar proliferation is often limited and unable to completely… read more here.

Keywords: acinar; mpj mice; proliferation; mrl mpj ... See more keywords
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Pharmacological Rescue of Ductal CFTR Rescue Pancreatic and Salivary glands Acinar Cells and Tissue Function in Mouse Models of Autoimmune diseases

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recommendations! Published in 2017 at "Gastroenterology"

DOI: 10.1053/j.gastro.2017.06.011

Abstract: Abstract Background & Aims Sjogren's syndrome and autoimmune pancreatitis (AIP) are disorders with decreased function of salivary, lacrimal glands, and the exocrine pancreas. NOD/ShiLTJ mice and mice transduced with the cytokine BMP6 develop Sjogren's syndrome… read more here.

Keywords: cftr; tissue; rescue; expression ... See more keywords
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The Combination of Alcohol and Cigarette Smoke Induces Endoplasmic Reticulum Stress and Cell Death in Pancreatic Acinar Cells.

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recommendations! Published in 2017 at "Gastroenterology"

DOI: 10.1053/j.gastro.2017.08.036

Abstract: BACKGROUND & AIMS Smoking, an independent risk factor for pancreatitis, accelerates the development of alcoholic pancreatitis. Alcohol feeding of mice induces up-regulation of spliced X-box binding protein 1 (XBP1s), which regulates the endoplasmic reticulum (ER)… read more here.

Keywords: acinar cells; cigarette smoke; death; cell death ... See more keywords