Polymorphisms in the IL‐1 gene cluster influence systemic inflammation in patients at risk for acute‐on‐chronic liver failure
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DOI: 10.1002/hep.28896
Abstract: Acute‐on‐chronic liver failure (ACLF) in cirrhosis is an increasingly recognized syndrome characterized by acute decompensation, organ failure(s) and high short‐term mortality. Recent findings suggest that an overexuberant systemic inflammation plays a primary role in ACLF… read more here.
Keywords: inflammation; gene cluster; aclf; failure ... See more keywords
Therapeutic plasma exchange is a safe and effective bridge therapy in patients with alcohol‐associated ACLF not having immediate prospects for liver transplantation—A case‐control, pilot study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Apheresis"
DOI: 10.1002/jca.22010
Abstract: Therapeutic plasma exchange (TPE) is a well‐established treatment modality in acute liver failure patients, but its efficacy in treating acute on chronic liver failure (ACLF) patients is yet to be established. read more here.
Keywords: therapeutic plasma; aclf; plasma exchange; exchange safe ... See more keywords
Serum ferritin diagnosis and prediction of hepatitis B virus‐related acute‐on‐chronic liver failure
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DOI: 10.1002/jmv.28183
Abstract: Early diagnosis and prediction of hepatitis B virus‐related acute‐on‐chronic liver failure (HBV‐ACLF) is important to reduce mortality. This study aimed to assess the diagnostic and predictive value of serum ferritin (SF) in HBV‐ACLF patients. Clinical… read more here.
Keywords: liver; hbv aclf; failure; aclf ... See more keywords
Risk Factors for Posttransplantation Mortality in Recipients With Grade 3 Acute‐on‐Chronic Liver Failure: Analysis of a North American Consortium
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DOI: 10.1002/lt.26408
Abstract: Although liver transplantation (LT) yields survival benefit for patients with acute‐on‐chronic liver failure grade 3 (ACLF‐3), knowledge gaps remain regarding risk factors for post‐LT mortality. We retrospectively reviewed data from 10 centers in the United… read more here.
Keywords: liver failure; failure; aclf; aclf aclf ... See more keywords
Role of interleukin-23 in monocyte-derived dendritic cells of HBV-related acute-on-chronic liver failure and its correlation with the severity of liver damage.
Sign Up to like & getrecommendations! Published in 2017 at "Clinics and research in hepatology and gastroenterology"
DOI: 10.1016/j.clinre.2016.10.005
Abstract: BACKGROUND The role of interleukin-23 (IL-23) in monocyte-derived dendritic cells (MoDCs) from hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) patients remains unclear. The aim of this study was to observe the correlation between the activation… read more here.
Keywords: aclf patients; hbv aclf; correlation; role ... See more keywords
World Gastroenterology Organisation classification and a new type-based prognostic model for hepatitis B virus-related acute-on-chronic liver failure.
Sign Up to like & getrecommendations! Published in 2020 at "Clinics and research in hepatology and gastroenterology"
DOI: 10.1016/j.clinre.2020.09.009
Abstract: BACKGROUND The acute-on-chronic liver failure (ACLF) classification, proposed by the World Gastroenterology Organisation (WGO), attempts to cover all ACLF patients diagnosed in the East and West. This study aimed to explore and establish a prognostic… read more here.
Keywords: classification; gastroenterology; model; aclf ... See more keywords
Prevalent acute-on-chronic liver failure and response to corticosteroids in alcoholic hepatitis.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2018.06.019
Abstract: To the Editor: We read the paper by Sersté et al. regarding the significance of acute-on-chronic liver failure (ACLF) in alcoholic hepatitis (AH) with interest. They conclude that ACLF in AH is associated with a… read more here.
Keywords: clif; aclf; chronic liver; failure ... See more keywords
Model for end-stage liver disease-sodium underestimates 90-day mortality risk in patients with acute-on-chronic liver failuare.
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DOI: 10.1016/j.jhep.2020.06.005
Abstract: BACKGROUND & AIMS The Model for End-stage Liver Disease with sodium correction (MELD-Na) is designed to prioritize liver transplantation (LT). MELD-Na predicts 90-day mortality in cirrhosis but it is unclear whether MELD-Na captures the clinical… read more here.
Keywords: mortality risk; mortality; day mortality; aclf ... See more keywords
Liver transplantation for patients with acute-on-chronic liver failure (ACLF) in Europe: results of the ELITA/EF-CLIF collaborative study (ECLIS).
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2021.03.030
Abstract: BACKGROUND AND AIMS Liver transplantation (LT) has been proposed to be an effective salvage therapy even for the sickest patients with acute-on-chronic liver failure (ACLF). This large collaborative study was designed to address the current… read more here.
Keywords: study; liver; liver transplantation; patients aclf ... See more keywords
Characteristics and outcomes of acute-on-chronic liver failure patients with or without cirrhosis using two criteria
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DOI: 10.1038/s41598-020-65529-5
Abstract: The aim of the study was to identify the characteristics and outcomes in acute-on-chronic liver failure (ACLF) patients with or without cirrhosis using two criteria. Patients with acute deterioration of chronic hepatic disease or acute… read more here.
Keywords: aclf patients; cirrhosis; easl aclf; aclf ... See more keywords
Inflammatory signature in acute-on-chronic liver failure includes increased expression of granulocyte genes ELANE, MPO and CD177
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DOI: 10.1038/s41598-021-98086-6
Abstract: Acute-on-Chronic Liver Failure (ACLF) is associated with innate immune dysfunction and high short-term mortality. Neutrophils have been identified to influence prognosis in ACLF. Neutrophil biology is under-evaluated in ACLF. Therefore, we investigated neutrophil-specific genes and… read more here.
Keywords: elane mpo; liver; genes elane; expression ... See more keywords