MicroRNA-124a contributes to glucocorticoid resistance in acute-on-chronic liver failure by negatively regulating glucocorticoid receptor alpha.
Sign Up to like & getrecommendations! Published in 2019 at "Annals of hepatology"
DOI: 10.1016/j.aohep.2019.08.007
Abstract: INTRODUCTION AND OBJECTIVES Glucocorticoid resistance frequently associating with inflammation, may severely compromise the therapeutic effect of glucocorticoids. In this study, we aimed to investigate the regulation of glucocorticoid resistance by microRNA-124a (miR-124a) in patients with… read more here.
Keywords: mir 124a; glucocorticoid resistance; 124a levels; aclf patients ... See more keywords
Role of interleukin-23 in monocyte-derived dendritic cells of HBV-related acute-on-chronic liver failure and its correlation with the severity of liver damage.
Sign Up to like & getrecommendations! Published in 2017 at "Clinics and research in hepatology and gastroenterology"
DOI: 10.1016/j.clinre.2016.10.005
Abstract: BACKGROUND The role of interleukin-23 (IL-23) in monocyte-derived dendritic cells (MoDCs) from hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) patients remains unclear. The aim of this study was to observe the correlation between the activation… read more here.
Keywords: aclf patients; hbv aclf; correlation; role ... See more keywords
The dynamic of platelet count as a novel and valuable predictor for 90-day survival of hepatitis B virus-related acute-on-chronic liver failure patients.
Sign Up to like & getrecommendations! Published in 2020 at "Clinics and research in hepatology and gastroenterology"
DOI: 10.1016/j.clinre.2020.06.008
Abstract: BACKGROUND The prognosis of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is extremely poor due to multiple organ dysfunction. OBJECTIVES To investigate the prognostic risk factors and create a 90-day prognostic predictive model for the… read more here.
Keywords: hbv aclf; day; aclf patients; hepatitis virus ... See more keywords
Characteristics and outcomes of acute-on-chronic liver failure patients with or without cirrhosis using two criteria
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-65529-5
Abstract: The aim of the study was to identify the characteristics and outcomes in acute-on-chronic liver failure (ACLF) patients with or without cirrhosis using two criteria. Patients with acute deterioration of chronic hepatic disease or acute… read more here.
Keywords: aclf patients; cirrhosis; easl aclf; aclf ... See more keywords
Imbalance Between Soluble and Membrane-Bound CD100 Regulates Monocytes Activity in Hepatitis B Virus-Associated Acute-on-Chronic Liver Failure.
Sign Up to like & getrecommendations! Published in 2021 at "Viral immunology"
DOI: 10.1089/vim.2020.0311
Abstract: CD100 is an important immune semaphorin that is a secreted and membrane bound protein involved in infectious diseases. However, CD100 expression profile and the regulation to innate immune system in hepatitis B virus (HBV)-associated acute-on-chronic… read more here.
Keywords: aclf patients; membrane bound; hbv aclf; cd100 ... See more keywords
Improved Survival With Higher-risk Donor Grafts in Liver Transplant With Acute-on-chronic Liver Failure
Sign Up to like & getrecommendations! Published in 2022 at "Transplantation Direct"
DOI: 10.1097/txd.0000000000001283
Abstract: Supplemental Digital Content is available in the text. Background. Use of higher-risk grafts in liver transplantation for patients with acute-on-chronic liver failure (ACLF) has been associated with poor outcomes. This study analyzes trends in liver… read more here.
Keywords: higher risk; aclf patients; transplantation; risk ... See more keywords
Pulmonary impairment independently determines mortality in critically ill patients with acute‐on‐chronic liver failure
Sign Up to like & getrecommendations! Published in 2022 at "Liver International"
DOI: 10.1111/liv.15343
Abstract: In ACLF patients, an adequate risk stratification is essential, especially for liver transplant allocation, since ACLF is associated with high short‐term mortality. The CLIF‐C ACLF score is the best prognostic model to predict outcome in… read more here.
Keywords: pulmonary impairment; aclf patients; failure; mortality ... See more keywords
OWE-015 Prostaglandin E2 mediates innate immune suppression in acute-on-chronic liver failure via the EP4 receptor
Sign Up to like & getrecommendations! Published in 2018 at "Gut"
DOI: 10.1136/gutjnl-2018-bsgabstracts.208
Abstract: Introduction Bacterial infection is a major cause of hospital admission in liver cirrhosis and patients are highly prone to nosocomial infection. Innate immune dysfunction is strongly implicated in these patients. We showed prostaglandin E2 (PGE2)… read more here.
Keywords: aclf patients; pge2; dysfunction; ep4 receptor ... See more keywords
The role of prophylactic antibiotics in hepatitis B virus-related acute-on-chronic liver failure patients at risk of bacterial infection: a retrospective study
Sign Up to like & getrecommendations! Published in 2021 at "Infectious Diseases of Poverty"
DOI: 10.1186/s40249-021-00830-7
Abstract: Background Acute-on-chronic liver failure (ACLF) is characterized by an excessive systemic inflammatory response and organ failure and has high mortality. Bacterial infections (BIs) worsen the clinical course of ACLF and carry a poor prognosis in… read more here.
Keywords: aclf patients; hbv aclf; prophylactic antibiotics; course ... See more keywords
Serum Nitric Oxide Level Serves as a Potential Prognostic Biomarker in ACLF Patients
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of General Medicine"
DOI: 10.2147/ijgm.s379837
Abstract: Background and Aim Fewer than 50% of patients with acute-on-chronic liver failure (ACLF) recover spontaneously, and without liver transplantation, ACLF is associated with high death rates. Nitric oxide (NO) has a role in the pathogenesis… read more here.
Keywords: aclf patients; aclf; serum level; nitric oxide ... See more keywords
Increased Circulating T Follicular Helper Cells Induced via IL-12/21 in Patients With Acute on Chronic Hepatitis B Liver Failure
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.641362
Abstract: Objectives T Follicular helper (Tfh) cells, recognized as a distinct CD4+ T cell subset, mediate the development of long-lived humoral immunity via B cell activation/differentiation. Tfh cells play an important role during hepatic viral infection,… read more here.
Keywords: hbv aclf; aclf patients; tfh cells;