ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.09.001
Abstract: ATP citrate lyase (ACLY) is a cytosolic homotetrameric enzyme that catalyzes the conversion of citrate and coenzyme A (CoA) to acetyl-CoA and oxaloacetate, with the simultaneous hydrolysis of ATP to ADP and phosphate. Interestingly, ACLY… read more here.
Keywords: atp citrate; citrate; acly inhibitors; metabolism ... See more keywords
ATP-citrate lyase (ACLY) inhibitors as therapeutic agents: a patenting perspective
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DOI: 10.1080/13543776.2022.2067478
Abstract: ABSTRACT Introduction ATP citrate lyase (ACLY) is a key enzyme in cellular metabolism, being the main source of acetyl-Coenzyme A, an important precursor for fatty acid, cholesterol, and isoprenoid biosynthesis, and it is also involved… read more here.
Keywords: citrate lyase; lyase acly; acly; atp citrate ... See more keywords
Discovery of Flavonoids as Novel Inhibitors of ATP Citrate Lyase: Structure–Activity Relationship and Inhibition Profiles
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DOI: 10.3390/ijms231810747
Abstract: ATP citrate lyase (ACLY) is a key enzyme in glucolipid metabolism and its aberrantly high expression is closely associated with various cancers, hyperlipemia and atherosclerotic cardiovascular diseases. Prospects of ACLY inhibitors as treatments of these… read more here.
Keywords: structure activity; structure; citrate lyase; atp citrate ... See more keywords