Elucidating tumour‐associated microglia/macrophage diversity along glioblastoma progression and under ACOD1 deficiency
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DOI: 10.1002/1878-0261.13287
Abstract: In glioblastoma (GBM), tumour‐associated microglia/macrophages (TAMs) represent the major cell type of the stromal compartment and contribute to tumour immune escape mechanisms. Thus, targeting TAMs is emerging as a promising strategy for immunotherapy. However, TAM… read more here.
Keywords: associated microglia; microglia macrophage; progression; tumour ... See more keywords
Aconitate decarboxylase 1 is a mediator of polymicrobial sepsis
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DOI: 10.1126/scitranslmed.abo2028
Abstract: Sepsis is a challenging clinical syndrome caused by a dysregulated host response to infection. Here, we identified an unexpected proseptic activity of aconitate decarboxylase 1 (ACOD1) in monocytes and macrophages. Previous studies have suggested that… read more here.
Keywords: sepsis; cdk2; aconitate decarboxylase; polymicrobial sepsis ... See more keywords
Macrophages inhibit Coxiella burnetii by the ACOD1‐itaconate pathway for containment of Q fever
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DOI: 10.15252/emmm.202215931
Abstract: Infection with the intracellular bacterium Coxiella (C.) burnetii can cause chronic Q fever with severe complications and limited treatment options. Here, we identify the enzyme cis- aconitate decarboxylase 1 (ACOD1 or IRG1) and its product… read more here.
Keywords: macrophages inhibit; itaconate; fever; coxiella burnetii ... See more keywords
Aconitate Decarboxylase 1 Deficiency Exacerbates Mouse Colitis Induced by Dextran Sodium Sulfate
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DOI: 10.3390/ijms23084392
Abstract: Ulcerative colitis is a complex inflammatory bowel disorder disease that can induce rectal and colonic dysfunction. Although the prevalence of IBD in Western countries is almost 0.5% of the general population, genetic causes are still… read more here.
Keywords: induced colitis; aconitate decarboxylase; itaconate; dss induced ... See more keywords